Pubblicazioni

Autori:

anna maria costa, ; Tommaso Lo Barco, ; Spezia, Elisabetta; Conti, Valerio; Roli, Laura; Marini, Lorenza; Minghetti, Sara; Caramaschi, Elisa; Pietrangelo, Laura; Pecoraro, Luca; D’Achille, Fabio; Accorsi, Paola; Trenti, Tommaso; Melani, Federico; Marini, Carla; Guerrini, Renzo; Darra, Francesca; Bergonzini, Patrizia; Biagini, G.

Titolo:

Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF PERSONALIZED MEDICINE

ISSN Rivista:

2075-4426

N° Volume:

12

Numero o Fascicolo:

4

Intervallo pagine:

1-13

Parole chiave:

antiseizure medications; children; epilepsy; generalized epilepsy; ghrelin; plasma

Breve descrizione dei contenuti:

Children with epilepsy and identified as responders to antiseizure medications (ASMs) were found to present markedly higher ghrelin plasma levels when compared to drug-resistant patients. However, it was undetermined if this phenotype could be influenced by the ASMs. Here, we prospectively investigated total ghrelin and des-acyl ghrelin (DAG) plasma levels by enzyme-linked immunosorbent assay before and after ASM administration. Inclusion criteria were: (i) subject with a suspicion of epilepsy; (ii) age ranging from 0 to 16 years; and (iii) informed consent signed by parents or caregivers. Exclusion criteria were acute or chronic metabolic disorders with occasional convulsions but without epilepsy. Fifty patients were followed over a period of one year in Italian neuropediatric centers. Apart from a few exceptions, the majority of children were responsive to ASMs. No differences were found in total ghrelin and DAG levels before and after the treatment, but total ghrelin levels were significantly lower in children with generalized epilepsy compared to those with combined focal and generalized epilepsy. Moreover, the ghrelin-to-DAG ratio was also markedly lower in generalized epilepsies compared to all the other types of epilepsy. Finally, ghrelin was unchanged by ASMs, including the first (e.g., carbamazepine), second (levetiracetam), and third (lacosamide) generation of anticonvulsants.

Id prodotto:

125778

Handle IRIS:

11562/1061846

ultima modifica:

31 ottobre 2024

Citazione bibliografica:

anna maria costa, ; Tommaso Lo Barco, ; Spezia, Elisabetta; Conti, Valerio; Roli, Laura; Marini, Lorenza; Minghetti, Sara; Caramaschi, Elisa; Pietrangelo, Laura; Pecoraro, Luca; D’Achille, Fabio; Accorsi, Paola; Trenti, Tommaso; Melani, Federico; Marini, Carla; Guerrini, Renzo; Darra, Francesca; Bergonzini, Patrizia; Biagini, G., Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies «JOURNAL OF PERSONALIZED MEDICINE» , vol. 12 , n. 4 , 2022 , pp. 1-13

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