Publications

Authors:

Chiricozzi, Andrea; Gori, Niccol(`(o)); Maurelli, Martina; Gisondi, Paolo; Caldarola, Giacomo; De Simone, Clara; Peris, Ketty; Girolomoni, Giampiero

Title:

Biological agents targeting interleukin-13 for atopic dermatitis

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

EXPERT OPINION ON BIOLOGICAL THERAPY

ISSN of journal:

1471-2598

:

Ashley Publications Limited:Unitec House, Third Floor, 2 Albert Place, Finchley Central, London N3 1QB United Kingdom:011 44 208 3433883, EMAIL: jdrake@ashley-pub.com, INTERNET: http://www.ashley-pub.com, Fax: 011 44 208 3432313

Page numbers:

1-9

Keyword:

ASLAN004; atopic dermatitis; interleukin 13; lebrikizumab; tralokinumab

Short description of contents:

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is pathogenically driven by type-2 inflammation. Interleukin-13 (IL-13) plays a central role in AD pathogenesis, as confirmed by the clinical efficacy of agents that selectively block IL-13, although their therapeutic value and place-in-therapy are incompletely defined. Areas covered: This review article aimed to describe preclinical and clinical data regarding selective IL-13 inhibitors investigated in AD. In particular, we discuss the clinical outcomes obtained with lebrikizumab and tralokinumab, which are in a more advanced phase of development. Expert opinion: Biological agents that neutralize IL-13 have demonstrated clinical benefits in treating AD with excellent safety profiles. Robust clinical evidence exists in support of tralokinumab, which underwent phase III trials, met the predefined primary endpoints, and is approaching the market. In contrast, clinical trial testing for lebrikizumab needs to be completed to fully assess its therapeutic potential.

Product ID:

126140

Handle IRIS:

11562/1063155

Last Modified:

October 9, 2024

Bibliographic citation:

Chiricozzi, Andrea; Gori, Niccol(`(o)); Maurelli, Martina; Gisondi, Paolo; Caldarola, Giacomo; De Simone, Clara; Peris, Ketty; Girolomoni, Giampiero, Biological agents targeting interleukin-13 for atopic dermatitis «EXPERT OPINION ON BIOLOGICAL THERAPY» , 2022 , pp. 1-9

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo