Publications

Authors:

Sabbadini, Fabio; Bertolini, Monica; De Matteis, Serena; Mangiameli, Domenico; Contarelli, Serena; Pietrobono, Silvia; Melisi, Davide

Title:

The Multifaceted Role of TGF-β in Gastrointestinal Tumors

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

CANCERS

ISSN of journal:

2072-6694

N° Volume:

13

Number or Folder:

16

Page numbers:

3960-3983

Keyword:

EMT; TGF-β; gastrointestinal tumors; immune plasticity; targeted therapy

Short description of contents:

: Transforming growth factor-beta (TGF-β) is a secreted cytokine that signals via serine/threonine kinase receptors and SMAD effectors. Although TGF-β acts as a tumor suppressor during the early stages of tumorigenesis, it supports tumor progression in advanced stages. Indeed, TGF-β can modulate the tumor microenvironment by modifying the extracellular matrix and by sustaining a paracrine interaction between neighboring cells. Due to its critical role in cancer development and progression, a wide range of molecules targeting the TGF-β signaling pathway are currently under active clinical development in different diseases. Here, we focused on the role of TGF-β in modulating different pathological processes with a particular emphasis on gastrointestinal tumors.

Product ID:

126206

Handle IRIS:

11562/1063596

Last Modified:

March 28, 2023

Bibliographic citation:

Sabbadini, Fabio; Bertolini, Monica; De Matteis, Serena; Mangiameli, Domenico; Contarelli, Serena; Pietrobono, Silvia; Melisi, Davide, The Multifaceted Role of TGF-β in Gastrointestinal Tumors «CANCERS» , vol. 13 , n. 16 , 2021 , pp. 3960-3983

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