Publications

Authors:

Wieczorek, Michele; Mariotto, Sara; Ferrari, Sergio; Mosna, Federico; Micò, Maria Caterina; Borghero, Carlo; Dubbini, Maria Vittoria; Malagola, Michele; Skert, Cristina; Andreini, Angelo; De Marco, Beatrice; Polo, Diana; Tfaily, Ahmad; Krampera, Mauro; Grassi, Anna; Candoni, Anna; Ranzato, Federica; Volonghi, Irene; Quatrale, Rocco; Benedetti, Fabio; Tecchio, Cristina

Title:

Neurological complications in adult allogeneic hematopoietic stem cell transplant patients: Incidence, characteristics and long-term follow-up in a multicenter series

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Bone Marrow Transplantation

ISSN of journal:

0268-3369

N° Volume:

57

Number or Folder:

7

Page numbers:

1133-1141

Keyword:

Diseases; Medical research

Short description of contents:

Neurological complications (NCs) represent a diagnostic and clinical challenge in allogeneic hematopoietic stem cell transplant (alloHSCT) patients. We retrospectively analyzed NC incidence, etiology, timing, characteristics, outcome, and long-term effects in 2384 adult patients transplanted in seven Italian institutions between January 2007 and December 2019. Ninety-three (3.9%) patients were affected by 96 NCs that were infectious (29.2%), immune/inflammatory (26%), drug-related (12.5%), cerebrovascular (5.2%), metabolic (3.1%), related to central nervous system disease relapse (11.5%) and malignancy (3.1%), or undefined (9.4%). Six patients (6.4%) had neurological manifestations of chronic graft-versus-host disease (GVHD). NCs occurred on average at day +128 (from -5 to +4063). Early (< day +120) and late NCs had similar frequencies (46.9% vs 53.1%, p = 0.39). Thirty-one patients (33.3%) were affected by acute or chronic GVHD at the NC onset. With a median follow-up of 25.4 (0.4-163) months, the overall mortality due to NCs was 22.6%. The median time between NC onset and death was 36 (1-269) days. Infectious NCs were the main cause (61.9%) of NC-related mortality. A persistent neurological impairment occurred in 20.4% patients, 57.9% of whom being affected by immune/inflammatory NCs. This study highlights the rare, yet severe impact of alloHSCT-associated NCs on patient survival and long-term functional ability.

Web page:

https://doi.org/10.1038/s41409-022-01690-x

Product ID:

126295

Handle IRIS:

11562/1063849

Last Modified:

November 15, 2022

Bibliographic citation:

Wieczorek, Michele; Mariotto, Sara; Ferrari, Sergio; Mosna, Federico; Micò, Maria Caterina; Borghero, Carlo; Dubbini, Maria Vittoria; Malagola, Michele; Skert, Cristina; Andreini, Angelo; De Marco, Beatrice; Polo, Diana; Tfaily, Ahmad; Krampera, Mauro; Grassi, Anna; Candoni, Anna; Ranzato, Federica; Volonghi, Irene; Quatrale, Rocco; Benedetti, Fabio; Tecchio, Cristina, Neurological complications in adult allogeneic hematopoietic stem cell transplant patients: Incidence, characteristics and long-term follow-up in a multicenter series «Bone Marrow Transplantation» , vol. 57 , n. 7 , 2022 , pp. 1133-1141

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo