Publications

Authors:

Simoni, Nicola; Micera, Renato; Rossi, Gabriella; Giri, Maria Grazia; Pavarana, Michele; Muraglia, Alessandro; Cernusco, Nunzia Luna Valentina; DE Liguoro, Mario; Guariglia, Stefania; Cavedon, Carlo; Milella, Michele; Mazzarotto, Renzo

Title:

Predictors of Local Control for Stereotactic Ablative Radiotherapy (SAbR) in Pulmonary Oligometastases from Gastrointestinal Malignancies

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

No

Name of journal:

ANTICANCER RESEARCH

ISSN of journal:

1791-7530

N° Volume:

40

Number or Folder:

10

Page numbers:

5901-5907

Keyword:

SAbR; gastrointestinal tumors; lung metastases; oligometastatic disease; Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Radiation; Female; Gastrointestinal Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Radiosurgery

Short description of contents:

Background/aim: To assess predictors of local control (LC) for stereotactic ablative radiotherapy (SAbR) in pulmonary oligometastatic disease (OMD) from gastrointestinal (GI) malignancies. Patients and methods: Patients with pulmonary OMD treated with SAbR from January 2016 to December 2018 were included in this observational analysis. Primary endpoint was LC. Uni- and multivariate analyses to assess variable correlations were conducted. Results: Thirty-seven patients and 59 lung metastases were evaluated. The delivered dose was 30-60 Gy in 3-8 fractions. After a median follow-up of 23.0 months (range=6.3-50.4 months), LC rate at 1/2 years was 89.7%/85.0%, and increased to 96.0%/91.0% for lesions treated with a biologically effective dose (BED10) ≥100 Gy (p=0.03). RECIST response at 6 months was predictive for LC (p=0.002). Conclusion: SAbR is an effective option for pulmonary OMD from GI malignancies. A BED10 ≥100 Gy and radiological response at 6 months can affect LC.

Product ID:

126376

Handle IRIS:

11562/1063998

Last Modified:

November 15, 2022

Bibliographic citation:

Simoni, Nicola; Micera, Renato; Rossi, Gabriella; Giri, Maria Grazia; Pavarana, Michele; Muraglia, Alessandro; Cernusco, Nunzia Luna Valentina; DE Liguoro, Mario; Guariglia, Stefania; Cavedon, Carlo; Milella, Michele; Mazzarotto, Renzo, Predictors of Local Control for Stereotactic Ablative Radiotherapy (SAbR) in Pulmonary Oligometastases from Gastrointestinal Malignancies «ANTICANCER RESEARCH» , vol. 40 , n. 10 , 2020 , pp. 5901-5907

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