Publications

Authors:

Bersanelli, Melissa; Giannarelli, Diana; Castrignanò, Paola; Fornarini, Giuseppe; Panni, Stefano; Mazzoni, Francesca; Tiseo, Marcello; Rossetti, Sabrina; Gambale, Elisabetta; Rossi, Ernesto; Papa, Anselmo; Cortellini, Alessio; Lolli, Cristian; Ratta, Raffaele; Michiara, Maria; Milella, Michele; De Luca, Emmanuele; Sorarù, Mariella; Mucciarini, Claudia; Atzori, Francesco; Banna, Giuseppe Luigi; La Torre, Leonardo; Vitale, Maria Giuseppa; Massari, Francesco; Rebuzzi, Sara Elena; Facchini, Gaetano; Schinzari, Giovanni; Tomao, Silverio; Bui, Simona; Vaccaro, Vanja; Procopio, Giuseppe; De Giorgi, Ugo; Santoni, Matteo; Ficorella, Corrado; Sabbatini, Roberto; Maestri, Antonio; Natoli, Clara; De Tursi, Michele; Di Maio, Massimo; Rapacchi, Elena; Pireddu, Annagrazia; Sava, Teodoro; Lipari, Helga; Comito, Francesca; Verzoni, Elena; Leonardi, Francesco; Buti, Sebastiano

Title:

INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

No

Name of journal:

IMMUNOTHERAPY: OPEN ACCESS

ISSN of journal:

2471-9552

N° Volume:

10

Number or Folder:

14

Page numbers:

1229-1239

Keyword:

Costimulatory and Inhibitory T-Cell Receptors; Female; Follow-Up Studies; Humans; Immunotherapy; Incidence; Influenza A virus; Influenza Vaccines; Influenza, Human; Italy; Male; Neoplasms; Retrospective Studies; Vaccination

Short description of contents:

Aim: Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. Methods: INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017. Results: Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001. Conclusion: Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.

Product ID:

126364

Handle IRIS:

11562/1064021

Last Modified:

November 15, 2022

Bibliographic citation:

Bersanelli, Melissa; Giannarelli, Diana; Castrignanò, Paola; Fornarini, Giuseppe; Panni, Stefano; Mazzoni, Francesca; Tiseo, Marcello; Rossetti, Sabrina; Gambale, Elisabetta; Rossi, Ernesto; Papa, Anselmo; Cortellini, Alessio; Lolli, Cristian; Ratta, Raffaele; Michiara, Maria; Milella, Michele; De Luca, Emmanuele; Sorarù, Mariella; Mucciarini, Claudia; Atzori, Francesco; Banna, Giuseppe Luigi; La Torre, Leonardo; Vitale, Maria Giuseppa; Massari, Francesco; Rebuzzi, Sara Elena; Facchini, Gaetano; Schinzari, Giovanni; Tomao, Silverio; Bui, Simona; Vaccaro, Vanja; Procopio, Giuseppe; De Giorgi, Ugo; Santoni, Matteo; Ficorella, Corrado; Sabbatini, Roberto; Maestri, Antonio; Natoli, Clara; De Tursi, Michele; Di Maio, Massimo; Rapacchi, Elena; Pireddu, Annagrazia; Sava, Teodoro; Lipari, Helga; Comito, Francesca; Verzoni, Elena; Leonardi, Francesco; Buti, Sebastiano, INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study «IMMUNOTHERAPY: OPEN ACCESS» , vol. 10 , n. 14 , 2018 , pp. 1229-1239

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo