Publications

Authors:

Venturi, Gabriele; Scarsini, Roberto; Pighi, Michele; Kotronias, Rafail A; Piccoli, Anna; Lunardi, Mattia; Del Sole, Paolo; Mainardi, Andrea; Gambaro, Alessia; Tavella, Domenico; De Maria, Giovanni L; Kharbanda, Rajesh; Pesarini, Gabriele; Banning, Adrian; Ribichini, Flavio

Title:

Volume of contrast to creatinine clearance ratio predicts early mortality and AKI after TAVI

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

ISSN of journal:

1522-1946

N° Volume:

99

Number or Folder:

6

Page numbers:

1925-1934

Keyword:

TAVI; acute kidney injury; outcomes; renal damage; Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Risk Factors; Treatment Outcome; Acute Kidney Injury; Aortic Valve Stenosis; Renal Insufficiency, Chronic; Transcatheter Aortic Valve Replacement

Short description of contents:

The volume of contrast to creatinine clearance ratio (CV/CrCl) is a useful indicator of the risk of acute kidney injury (AKI) in patients undergoing percutaneous interventional procedures. Association between CV/CrCl and adverse outcome after transcatheter aortic valve implantation (TAVI) was suggested but it is not well established. A large retrospective multicenter cohort of 1381 patients treated with TAVI was analyzed to assess the association between CV/CrCl and the risk of AKI and mortality at 90 days and 1 year after TAVI. Patients receiving renal replacement therapy at the time of TAVI were excluded. CV/CrCl >= 2.2 was associated with the risk of AKI and 90 days mortality after TAVI after adjustment for age, sex, diabetes, baseline left ventricular function, baseline chronic kidney disease (CKD), previous myocardial infarction and peripheral vascular disease (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 1.09-1.22, p < 0.0001). Importantly, CV/CrCl was associated with the adverse outcome independently from the presence of baseline CKD (p for interaction = 0.22). CV/CrCl was independently associated with the individual components of the composite primary outcome including AKI (odds ratio: 1.18, 95% CI: 1.08-1.28, p < 0.0001) and 90 days mortality (HR: 1.90, 95% CI: 1.01-3.60, p = 0.047) after TAVI. AKI (HR: 1.94, 95% CI: 1.21-3.11, p = 0.006) but not CV/CrCl was associated with the risk of 1-year mortality after TAVI. CV/CrCl is associated with excess renal damage and early mortality after TAVI. Procedural strategies to minimize the CV/CrCl during TAVI may improve early clinical outcomes in patients undergoing TAVI.

Product ID:

128132

Handle IRIS:

11562/1072395

Last Modified:

February 23, 2023

Bibliographic citation:

Venturi, Gabriele; Scarsini, Roberto; Pighi, Michele; Kotronias, Rafail A; Piccoli, Anna; Lunardi, Mattia; Del Sole, Paolo; Mainardi, Andrea; Gambaro, Alessia; Tavella, Domenico; De Maria, Giovanni L; Kharbanda, Rajesh; Pesarini, Gabriele; Banning, Adrian; Ribichini, Flavio, Volume of contrast to creatinine clearance ratio predicts early mortality and AKI after TAVI «CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS» , vol. 99 , n. 6 , 2022 , pp. 1925-1934

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo