Pubblicazioni

Autori:

Bezzerri, Valentino; Gentili, Valentina; Api, Martina; Finotti, Alessia; Papi, Chiara; Tamanini, Anna; Boni, Christian; Baldisseri, Elena; Olioso, Debora; Duca, Martina; Tedesco, Erika; Leo, Sara; Borgatti, Monica; Volpi, Sonia; Pinton, Paolo; Cabrini, Giulio; Gambari, Roberto; Blasi, Francesco; Lippi, Giuseppe; Rimessi, Alessandro; Rizzo, Roberta; Cipolli, Marco

Titolo:

SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

NATURE COMMUNICATIONS

ISSN Rivista:

2041-1723

N° Volume:

14

Numero o Fascicolo:

1

Intervallo pagine:

132-132

Parole chiave:

COVID-19; SARS-CoV-2; cystic fibrosis; vaccine

Breve descrizione dei contenuti:

As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. Instead, current clinical evidence seems to be heading in the opposite direction. To clarify whether host factors expressed by the Cystic Fibrosis epithelia may influence coronavirus disease 2019 progression, here we describe the expression of SARS-CoV-2 receptors in primary airway epithelial cells. We show that angiotensin converting enzyme 2 (ACE2) expression and localization are regulated by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Consistently, our results indicate that dysfunctional CFTR channels alter susceptibility to SARS-CoV-2 infection, resulting in reduced viral entry and replication in Cystic Fibrosis cells. Depending on the pattern of ACE2 expression, the SARS-CoV-2 spike (S) protein induced high levels of Interleukin 6 in healthy donor-derived primary airway epithelial cells, but a very weak response in primary Cystic Fibrosis cells. Collectively, these data support that Cystic Fibrosis condition may be at least partially protecting from SARS-CoV-2 infection.

Pagina Web:

https://www.nature.com/articles/s41467-023-35862-0

Id prodotto:

131084

Handle IRIS:

11562/1082168

ultima modifica:

16 febbraio 2025

Citazione bibliografica:

Bezzerri, Valentino; Gentili, Valentina; Api, Martina; Finotti, Alessia; Papi, Chiara; Tamanini, Anna; Boni, Christian; Baldisseri, Elena; Olioso, Debora; Duca, Martina; Tedesco, Erika; Leo, Sara; Borgatti, Monica; Volpi, Sonia; Pinton, Paolo; Cabrini, Giulio; Gambari, Roberto; Blasi, Francesco; Lippi, Giuseppe; Rimessi, Alessandro; Rizzo, Roberta; Cipolli, Marco, SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation «NATURE COMMUNICATIONS» , vol. 14 , n. 1 , 2023 , pp. 132-132

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo