Publications

Authors:

Cattazzo, F.; Lombardi, R.; Mantovani, A.; Bevilacqua, M.; Zoncapè, M.; Iogna Prat, L.; Roccarina, D.; Fortuna, L.; Cespiati, A.; Sacerdoti, D.; Fracanzani, A. L.; Tsochatzis, E.; Fava, C.; Dalbeni, A.

Title:

Subclinical and clinical atherosclerosis in Non-alcoholic Fatty Liver Disease is associated with the presence of hypertension

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Nutrition in Metabolic and Cardiovascular Diseases

ISSN of journal:

0939-4753

N° Volume:

32

Page numbers:

2839-2847

Keyword:

liver, NAFLD, atherosclerosis

Short description of contents:

Background and aims Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. However, whether NAFLD contributes independently to the development of cardiovascular disease is not fully understood. Our study aimed at assessing the differences in several indices of atherosclerosis, arterial stiffness and cardiac morphology among patients with isolated NAFLD, isolated hypertension (HT) or with combination of the two conditions. Methods and results One hundred and sixty-nine participants (mean age=50.4±10.2 yrs; males=73.6 %) were divided according to the presence of NAFLD and HT in three groups: only-NAFLD (55 patients), only-HT (49 patients) and NAFLD+HT (65 patients). Exclusion criteria were BMI≥35Kg/m2 and presence of diabetes mellitus. Carotid ultrasonography was performed to measure markers of atherosclerosis and arterial stiffness. Cardiac remodeling was analyzed using echocardiography. Prevalence of subclinical and overt atherosclerosis was significantly higher in the NAFLD+HT patients as compared to the other two groups (atherosclerotic plaques: 43.1%, 10.9%, 22.4% (p<0.001), in NAFLD+HT, NAFLD and HT groups). No differences were found among indices of arterial stiffening and cardiac remodeling across the three groups. In multivariate regression analysis the coexistence of NAFLD and HT was an independent risk factor for overt atherosclerosis (OR=4.88; p=0.03), while no association was found when either NAFLD or HT was considered alone. Conclusion Overt atherosclerosis was significantly present only in NAFLD+HT patients, but not in patients presenting with isolated NAFLD. This implies that the impact of NAFLD on vascular structure and function could depend on the coexistence of other major cardiovascular risk factors, such as HT.

Note:

International collaborative study

Product ID:

131475

Handle IRIS:

11562/1082311

Last Modified:

May 11, 2024

Bibliographic citation:

Cattazzo, F.; Lombardi, R.; Mantovani, A.; Bevilacqua, M.; Zoncapè, M.; Iogna Prat, L.; Roccarina, D.; Fortuna, L.; Cespiati, A.; Sacerdoti, D.; Fracanzani, A. L.; Tsochatzis, E.; Fava, C.; Dalbeni, A., Subclinical and clinical atherosclerosis in Non-alcoholic Fatty Liver Disease is associated with the presence of hypertension «Nutrition in Metabolic and Cardiovascular Diseases» , vol. 32 , 2022 , pp. 2839-2847

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