Publications

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study  (2021)

Authors:
Collaborative, Covidsurg; Collaborative, Globalsurg; Campagnaro, Tommaso; Caravati, Andrea; Conci, Simone; DE CRISTOFARO, Carlotta; Gecchele, Gabriele; Giuliani, Tommaso; Graziosi, Jacopo; Guglielmi, Alfredo; Paiella, Salvatore; Pedrazzani, Corrado; Pollini, Tommaso; Rattizzato, Simone; Ruzzenente, Andrea; Salvia, Roberto; Turri, Giulia
Title:
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Year:
2021
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
No
Name of journal:
British Journal of Surgery
ISSN of journal:
0007-1323
N° Volume:
108
Number or Folder:
9
Page numbers:
1056-1063
Keyword:
covid-19
Short description of contents:
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.
Product ID:
131264
Handle IRIS:
11562/1083524
Last Modified:
February 23, 2023
Bibliographic citation:
Collaborative, Covidsurg; Collaborative, Globalsurg; Campagnaro, Tommaso; Caravati, Andrea; Conci, Simone; DE CRISTOFARO, Carlotta; Gecchele, Gabriele; Giuliani, Tommaso; Graziosi, Jacopo; Guglielmi, Alfredo; Paiella, Salvatore; Pedrazzani, Corrado; Pollini, Tommaso; Rattizzato, Simone; Ruzzenente, Andrea; Salvia, Roberto; Turri, Giulia, SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study «British Journal of Surgery» , vol. 108 , n. 92021pp. 1056-1063

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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