Pubblicazioni

Autori:

Girolami, Ilaria; Marletta, Stefano; Fiorentino, Vincenzo; Battocchio, Simonetta; Cerbelli, Bruna; Fiamengo, Barbara; Gerosa, Clara; Gianatti, Andrea; Morelli, Luca; Riva, Giulio; Zagami, Maria Giovanna; Fusco, Nicola; Munari, Enrico; L'Imperio, Vincenzo; Pagni, Fabio; Morbini, Patrizia; Martini, Maurizio; Eccher, Albino

Titolo:

Effect of Radio-Chemotherapy on PD-L1 Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

JOURNAL OF PERSONALIZED MEDICINE

ISSN Rivista:

2075-4426

N° Volume:

13

Numero o Fascicolo:

2

Intervallo pagine:

1-12

Parole chiave:

head and neck squamous cell carcinoma; immunohistochemistry; immunotherapy; programmed death-ligand 1; radio-chemotherapy; systematic review

Breve descrizione dei contenuti:

Background: Programmed death-ligand 1 (PD-L1) checkpoint inhibitors represent a mainstay of therapy in head and neck squamous cell cancer (HNSCC). However, little is known about the influence of combined therapy on PD-L1 expression. The study aims to gather evidence on this topic. Methods: A systematic search was carried out in electronic databases Pubmed-MEDLINE and Embase to retrieve studies on the comparison of PD-L1 expression before and after conventional therapy. Data were extracted and a quantitative analysis with pooled odds ratios (ORs) was performed when applicable. Results: Of 5688 items, 15 were finally included. Only a minority of studies assessed PD-L1 with the recommended combined positive score (CPS). The results are highly heterogeneous, with some studies reporting an increase in PD-L1 expression and others reporting a decrease. Three studies allowed for quantitative analysis and showed a pooled OR of 0.49 (CI 0.27-0.90). Conclusions: From the present evidence, a clear conclusion towards an increase or decrease in PD-L1 expression after combined therapy cannot be drawn, but even with few studies available, a trend towards an increase in expression in tumor cells at a cutoff of 1% can be noted in patients undergoing platinum-based therapy. Future studies will provide more robust data on the effect of combined therapy on PD-L1 expression.

Id prodotto:

132215

Handle IRIS:

11562/1086630

ultima modifica:

28 marzo 2023

Citazione bibliografica:

Girolami, Ilaria; Marletta, Stefano; Fiorentino, Vincenzo; Battocchio, Simonetta; Cerbelli, Bruna; Fiamengo, Barbara; Gerosa, Clara; Gianatti, Andrea; Morelli, Luca; Riva, Giulio; Zagami, Maria Giovanna; Fusco, Nicola; Munari, Enrico; L'Imperio, Vincenzo; Pagni, Fabio; Morbini, Patrizia; Martini, Maurizio; Eccher, Albino, Effect of Radio-Chemotherapy on PD-L1 Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma «JOURNAL OF PERSONALIZED MEDICINE» , vol. 13 , n. 2 , 2023 , pp. 1-12

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