Pubblicazioni

CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2  (2023)

Autori:
Lagni, Anna; Lotti, Virginia; Diani, Erica; Rossini, Giada; Concia, Ercole; Sorio, Claudio; Gibellini, Davide
Titolo:
CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2
Anno:
2023
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Referee:
No
Nome rivista:
CELLS
ISSN Rivista:
2073-4409
N° Volume:
12
Numero o Fascicolo:
5
Intervallo pagine:
1-15
Parole chiave:
CFTR; CFTR inhibitors; IOWH-032; PPQ-102; SARS-CoV-2; antiviral; cystic fibrosis
Breve descrizione dei contenuti:
: Several reports have indicated that SARS-CoV-2 infection displays unexpected mild clinical manifestations in people with cystic fibrosis (pwCF), suggesting that CFTR expression and function may be involved in the SARS-CoV-2 life cycle. To evaluate the possible association of CFTR activity with SARS-CoV-2 replication, we tested the antiviral activity of two well-known CFTR inhibitors (IOWH-032 and PPQ-102) in wild type (WT)-CFTR bronchial cells. SARS-CoV-2 replication was inhibited by IOWH-032 treatment, with an IC50 of 4.52 μM, and by PPQ-102, with an IC50 of 15.92 μM. We confirmed this antiviral effect on primary cells (MucilAirTM wt-CFTR) using 10 μM IOWH-032. According to our results, CFTR inhibition can effectively tackle SARS-CoV-2 infection, suggesting that CFTR expression and function might play an important role in SARS-CoV-2 replication, revealing new perspectives on the mechanisms governing SARS-CoV-2 infection in both normal and CF individuals, as well as leading to potential novel treatments.
Id prodotto:
132733
Handle IRIS:
11562/1087727
ultima modifica:
17 maggio 2023
Citazione bibliografica:
Lagni, Anna; Lotti, Virginia; Diani, Erica; Rossini, Giada; Concia, Ercole; Sorio, Claudio; Gibellini, Davide, CFTR Inhibitors Display In Vitro Antiviral Activity against SARS-CoV-2 «CELLS» , vol. 12 , n. 52023pp. 1-15

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