Pubblicazioni

Autori:

Caputo, Alessandro; Fraggetta, Filippo; Cretella, Pasquale; Cozzolino, Immacolata; Eccher, Albino; Girolami, Ilaria; Marletta, Stefano; Troncone, Giancarlo; Vigliar, Elena; Acanfora, Gennaro; Zarra, Karen Villar; Torres Rivas, Héctor Enrique; Fadda, Guido; Field, Andrew; Katz, Ruth; Vielh, Philippe; Eloy, Catarina; Rajwanshi, Arvind; Gupta, Nalini; Al-Abbadi, Mousa; Bustami, Nadwa; Arar, Tala; Calaminici, Maria; Raine, Juliet I; Barroca, Helena; Canão, Pedro Amoroso; Ehinger, Mats; Rajabian, Nilofar; Dey, Pranab; Medeiros, L Jeffrey; El Hussein, Siba; Lin, Oscar; D'Antonio, Antonio; Bode-Lesniewska, Beata; Rossi, Esther Diana; Zeppa, Pio

Titolo:

Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS). An international, multi-institutional study

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

CANCER CYTOPATHOLOGY

ISSN Rivista:

1934-662X

N° Volume:

131

Numero o Fascicolo:

11

Intervallo pagine:

679-692

Parole chiave:

digital cytopathology; lymph node; reproducibility; virtual microscopy; whole-slide imaging

Breve descrizione dei contenuti:

Background: After a series of standardized reporting systems in cytopathology, the Sydney system was recently introduced to address the need for reproducibility and standardization in lymph node cytopathology. Since then, the risk of malignancy for the categories of the Sydney system has been explored by several studies, but no studies have yet examined the interobserver reproducibility of the Sydney system. Methods: The authors assessed interobserver reproducibility of the Sydney system on 85 lymph node fine-needle aspiration cytology cases reviewed by 15 cytopathologists from 12 institutions in eight different countries, resulting in 1275 diagnoses. In total, 186 slides stained with Diff-Quik, Papanicolaou, and immunocytochemistry were scanned. A subset of the cases included clinical data and results from ultrasound examinations, flow cytometry immunophenotyping, and fluorescence in situ hybridization analysis. The study participants assessed the cases digitally using whole-slide images. Results: Overall, the authors observed an almost perfect agreement of cytopathologists with the ground truth (median weighted Cohen κ = 0.887; interquartile range, κ = 0.210) and moderate overall interobserver concordance (Fleiss κ = 0.476). There was substantial agreement for the inadequate and malignant categories (κ = 0.794 and κ = 0.729, respectively), moderate agreement for the benign category (κ = 0.490), and very slight agreement for the suspicious (κ = 0.104) and atypical (κ = 0.075) categories. Conclusions: The Sydney system for reporting lymph node cytopathology shows adequate interobserver concordance. Digital microscopy is an adequate means to assess lymph node cytopathology specimens.

Note:

Epub 2023 Jul 7

Id prodotto:

134588

Handle IRIS:

11562/1098926

ultima modifica:

5 novembre 2023

Citazione bibliografica:

Caputo, Alessandro; Fraggetta, Filippo; Cretella, Pasquale; Cozzolino, Immacolata; Eccher, Albino; Girolami, Ilaria; Marletta, Stefano; Troncone, Giancarlo; Vigliar, Elena; Acanfora, Gennaro; Zarra, Karen Villar; Torres Rivas, Héctor Enrique; Fadda, Guido; Field, Andrew; Katz, Ruth; Vielh, Philippe; Eloy, Catarina; Rajwanshi, Arvind; Gupta, Nalini; Al-Abbadi, Mousa; Bustami, Nadwa; Arar, Tala; Calaminici, Maria; Raine, Juliet I; Barroca, Helena; Canão, Pedro Amoroso; Ehinger, Mats; Rajabian, Nilofar; Dey, Pranab; Medeiros, L Jeffrey; El Hussein, Siba; Lin, Oscar; D'Antonio, Antonio; Bode-Lesniewska, Beata; Rossi, Esther Diana; Zeppa, Pio, Digital Examination of LYmph node CYtopathology Using the Sydney system (DELYCYUS). An international, multi-institutional study «CANCER CYTOPATHOLOGY» , vol. 131 , n. 11 , 2023 , pp. 679-692

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo