Publications

Ultrasound-derived fat fraction for detection of hepatic steatosis and quantification of liver fat content  (2023)

Authors:
De Robertis, Riccardo; Spoto, Flavio; Autelitano, Daniele; Guagenti, Daniela; Olivieri, Antonia; Zanutto, Piero; Incarbone, Greta; D'Onofrio, Mirko
Title:
Ultrasound-derived fat fraction for detection of hepatic steatosis and quantification of liver fat content
Year:
2023
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Referee:
No
Name of journal:
La Radiologia Medica
ISSN of journal:
1826-6983
N° Volume:
128
Number or Folder:
10
Page numbers:
1174-1180
Keyword:
Fatty liver; Liver; Magnetic resonance; Non-alcoholic fatty liver disease; Ultrasound
Short description of contents:
PurposeTo compare ultrasound (US) and US-derived fat fraction (UDFF) with magnetic resonance proton density fat fraction (MRI-PDFF) for the detection of hepatic steatosis and quantification of liver fat content.Materials and methodsBetween October and December 2022, 149 patients scheduled for an abdominal MRI agreed to participate in this study and underwent MRI-PDFF, US and UDFF. Inclusion criteria were: (a) no chronic liver disease or jaundice; (b) no MRI motion artifacts; (c) adequate liver examination at US. Exclusion criteria were: (a) alcohol abuse, chronic hepatitis, cirrhosis, or jaundice; (b) MRI artifacts or insufficient US examination. The median of 10 MRI-PDFF and UDFF measurements in the right hepatic lobe was analyzed. UDFF and MRI-PDFF were compared by Bland-Altman difference plot and Pearson's test. Sensitivity, specificity, positive and negative predictive values, accuracy, and area under the receiver-operator curve (AUC-ROC) of US and UDFF were calculated using an MRI-PDFF cut-off value of 5%. p values & LE; 0.05 were statistically significant.Results122 patients were included (61 men, mean age 60 years, standard deviation 15 years). The median MRI-PDFF value was 4.1% (interquartile range 2.9-6); 37.7% patients had a median MRI-PDFF value & GE; 5%. UDFF and MRI-PDFF had high agreement (p = 0.11) and positive correlation (⍴ = 0.81, p < 0.001). UDFF had a higher diagnostic value than US for the detection of steatosis, with AUC-ROCs of 0.75 (95% CI 0.65, 0.84) and 0.53 (95% CI 0.42, 0.64), respectively.ConclusionsUDFF reliably quantifies liver fat content and improves the diagnostic value of US for the detection of hepatic steatosis.
Product ID:
134964
Handle IRIS:
11562/1102067
Last Modified:
December 18, 2024
Bibliographic citation:
De Robertis, Riccardo; Spoto, Flavio; Autelitano, Daniele; Guagenti, Daniela; Olivieri, Antonia; Zanutto, Piero; Incarbone, Greta; D'Onofrio, Mirko, Ultrasound-derived fat fraction for detection of hepatic steatosis and quantification of liver fat content «La Radiologia Medica» , vol. 128 , n. 102023pp. 1174-1180

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