Pubblicazioni

Autori:

Zhou, Xiao-Dong; Chen, Qin-Fen; Targher, Giovanni; Byrne, Christopher D; Shapiro, Michael D; Tian, Na; Xiao, Tie; Sung, Ki-Chul; Lip, Gregory Y H; Zheng, Ming-Hua

Titolo:

High-Sensitivity C-Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE

ISSN Rivista:

2047-9980

Intervallo pagine:

032997-033006

Parole chiave:

heart failure hospitalization; heart failure with preserved ejection fraction; high‐sensitivity C‐reactive protein; metabolic dysfunction‐associated fatty liver disease; metabolic dysfunction‐associated steatotic liver disease

Breve descrizione dei contenuti:

Background: Systemic chronic inflammation plays a role in the pathophysiology of both heart failure with preserved ejection fraction (HFpEF) and metabolic dysfunction-associated fatty liver disease. This study aimed to investigate whether serum hs-CRP (high-sensitivity C-reactive protein) levels were associated with the future risk of heart failure (HF) hospitalization in patients with metabolic dysfunction-associated fatty liver disease and a normal left ventricular ejection fraction. Methods and results: The study enrolled consecutive individuals with metabolic dysfunction-associated fatty liver disease and normal left ventricular ejection fraction who underwent coronary angiography for suspected coronary heart disease. The study population was subdivided into non-HF, pre-HFpEF, and HFpEF groups at baseline. The study outcome was time to the first hospitalization for HF. In 10 019 middle-aged individuals (mean age, 63.3±10.6 years; 38.5% women), the prevalence rates of HFpEF and pre-HFpEF were 34.2% and 34.5%, with a median serum hs-CRP level of 4.5 mg/L (interquartile range, 1.9-10 mg/L) and 5.0 mg/L (interquartile range, 2.1-10.1 mg/L), respectively. Serum hs-CRP levels were significantly higher in the pre-HFpEF and HFpEF groups than in the non-HF group. HF hospitalizations occurred in 1942 (19.4%) patients over a median of 3.2 years, with rates of 3.7% in non-HF, 20.8% in pre-HFpEF, and 32.1% in HFpEF, respectively. Cox regression analyses showed that patients in the highest hs-CRP quartile had a ≈4.5-fold increased risk of being hospitalized for HF compared with those in the lowest hs-CRP quartile (adjusted-hazard ratio, 4.42 [95% CI, 3.72-5.25]). Conclusions: There was a high prevalence of baseline pre-HFpEF and HFpEF in patients with metabolic dysfunction-associated fatty liver disease and suspected coronary heart disease. There was an increased risk of HF hospitalization in those with elevated hs-CRP levels.

Id prodotto:

137470

Handle IRIS:

11562/1118327

ultima modifica:

30 ottobre 2024

Citazione bibliografica:

Zhou, Xiao-Dong; Chen, Qin-Fen; Targher, Giovanni; Byrne, Christopher D; Shapiro, Michael D; Tian, Na; Xiao, Tie; Sung, Ki-Chul; Lip, Gregory Y H; Zheng, Ming-Hua, High-Sensitivity C-Reactive Protein Is Associated With Heart Failure Hospitalization in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease and Normal Left Ventricular Ejection Fraction Undergoing Coronary Angiography «JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE» , 2024 , pp. 032997-033006

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo