Pubblicazioni

Autori:

De Bellis, Mario; Mastrosimini, Maria Gaia; Capelli, Paola; Alaimo, Laura; Conci, Simone; Campagnaro, Tommaso; Pecori, Sara; Scarpa, Aldo; Guglielmi, Alfredo; Ruzzenente, Andrea

Titolo:

The Relevance of Radial Margin Status in Perihilar Cholangiocarcinoma: A State-of-the-Art Narrative Review

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Digestive Surgery

ISSN Rivista:

0253-4886

N° Volume:

41

Numero o Fascicolo:

2

Intervallo pagine:

92-102

Parole chiave:

Perihilar cholangiocarcinoma; Radial margin; Radical resection; Residual disease; Surgical margin

Breve descrizione dei contenuti:

Background: Prognosis of perihilar cholangiocarcinoma (PHCC) is poor, and curative-intent resection is the most effective treatment associated with long-term survival. Surgery is technically demanding since it involves a major hepatectomy with en bloc resection of the caudate lobe and extrahepatic bile duct. Furthermore, to achieve negative margins, it may be necessary to perform concomitant vascular resection or pancreatoduodenectomy. Despite this aggressive approach, recurrence is often observed, considering 5-year recurrence-free survival below 15% and 5-year overall survival that barely exceeds 40%. Summary: The literature reports that survival rates are better in patients with negative margins, and surprisingly, R0 resections range between 19% and 95%. This variability is probably due to different surgical strategies and the pathologist's expertise with specimens. In fact, a proper pathological examination of residual disease should take into consideration both the ductal and the radial margin (RM) status. Currently, detailed pathological reports are lacking, and there is a likelihood of misinterpreting residual disease status due to the missing of RM description and the utilization of various definitions for surgical margins. Key messages: The aim of PHCC surgery is to achieve negative margins including RM. More clarity in reporting on RM is needed to define true radical resection and consistent design of oncological studies for adjuvant treatments.

Note:

Epub 2024 Mar 6

Id prodotto:

139080

Handle IRIS:

11562/1125010

ultima modifica:

12 maggio 2024

Citazione bibliografica:

De Bellis, Mario; Mastrosimini, Maria Gaia; Capelli, Paola; Alaimo, Laura; Conci, Simone; Campagnaro, Tommaso; Pecori, Sara; Scarpa, Aldo; Guglielmi, Alfredo; Ruzzenente, Andrea, The Relevance of Radial Margin Status in Perihilar Cholangiocarcinoma: A State-of-the-Art Narrative Review «Digestive Surgery» , vol. 41 , n. 2 , 2024 , pp. 92-102

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