Publications

Authors:

Fantin, Francesco; Giani, Anna; Manzato, Gisella; Zampieri, Annachiara; Comellato, Gabriele; Urbani, Silvia; Zoico, Elena; Mazzali, Gloria; Zamboni, Mauro

Title:

Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

FRONTIERS IN CARDIOVASCULAR MEDICINE

ISSN of journal:

2297-055X

N° Volume:

8

Number or Folder:

11

Page numbers:

1-8

Keyword:

arterial stiffness, cardio-ankle vascular index, obesity, pulse wave velocity, sarcopenia, sarcopenic obesity

Short description of contents:

Background: Aging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arterial stiffness in older adults. Methods: A total of 77 hospitalized patients (mean age 78.68 ± 9.65 years) were evaluated, obtaining anthropometric variables, biochemical samples, handgrip test, and body composition assessment. Arterial stiffness was evaluated by measuring both carotid-femoral pulse wave velocity (cfPWV), a proxy for central stiffness, and cardio-ankle vascular index (CAVI), as well as considering peripheral arteries. The population was sorted into four subgroups: obese, sarcopenic, SO, and controls. Results: The highest CAVI (11.31 ± 2.58) was found in sarcopenic patients. SO had the highest value of cfPWV (15.18 ± 8.44 m/s), even after adjustment for significant covariates. In multiple regressions, SO diagnosis resulted as a significant predictor of cfPWV (p = 0.03, R2 = 0.20), and sarcopenia diagnosis resulted as a predictor of CAVI (p = 0.042, R2 = 0.12). Conclusions: In conclusion, a positive correlation is found between sarcopenia, SO, and arterial stiffness among older subjects. In particular, greater central arterial stiffness is associated with SO, outlining a remarkable effect on the cardiovascular risk profile.

Product ID:

139455

Handle IRIS:

11562/1126017

Last Modified:

May 10, 2024

Bibliographic citation:

Fantin, Francesco; Giani, Anna; Manzato, Gisella; Zampieri, Annachiara; Comellato, Gabriele; Urbani, Silvia; Zoico, Elena; Mazzali, Gloria; Zamboni, Mauro, Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults «FRONTIERS IN CARDIOVASCULAR MEDICINE» , vol. 8 , n. 11 , 2024 , pp. 1-8

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