Publications

Authors:

Dalbeni, Andrea; Cattazzo, Filippo; De Marco, Leonardo; Bevilacqua, Michele; Zoncapè, Mirko; Lombardi, Rosa; Stupia, Roberta; Mantovani, Anna; Sacerdoti, David

Title:

Bacterial infections as a risk factor for non-neoplastic portal vein thrombosis development in cirrhotic patients

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Digestive Liver Disease

ISSN of journal:

1590-8658

N° Volume:

56

Number or Folder:

3

:

EGI srl

Page numbers:

477-483

Keyword:

Bacterial infections; Cirrhosis; Hepatic decompensation; MDROs; Non-neoplastic portal vein thrombosis; Ultrasound

Short description of contents:

Background: Portal vein thrombosis (PVT) and sepsis are common complications in patients with liver cirrhosis. Factors that lead to PVT are not completely understood. This study aimed to investigate the possible association between bacterial infections and the development of PVT in cirrhotic patients. Patients and Methods: 202 consecutive cirrhotic patients without previous infections, followed at the Liver Unit in Verona Hospital, were enrolled from 2017 to 2021 (median follow-up 3.3 years). During the follow-up period, PVT was diagnosed by ultrasound, CT and/or MRI, and episodes of bacterial infections requiring hospitalization were recorded. Malignant PVT was an exclusion criterion. Results: Of the 202 patients enrolled (68.3 % males, mean age 63.8 +/- 11 years), 22 (10.8 %) developed PVT during the follow up. In patients with PVT, the prevalence of previous bacterial infections was significantly higher compared to patients without PVT (63.6% vs 31.1 %; p = 0.02). Cox regression analysis revealed that a history of bacterial infection was the only variable that demonstrated a significant association with the risk of de novo PVT occurrence (HR 4.04, 95 % CI: 1.68-9.65). Conclusion: in patients with liver cirrhosis bacterial infections are a predisposing factor for the following development of PVT. Further studies are needed to confirm this evidence. (c) 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Product ID:

139499

Handle IRIS:

11562/1126106

Last Modified:

August 24, 2024

Bibliographic citation:

Dalbeni, Andrea; Cattazzo, Filippo; De Marco, Leonardo; Bevilacqua, Michele; Zoncapè, Mirko; Lombardi, Rosa; Stupia, Roberta; Mantovani, Anna; Sacerdoti, David, Bacterial infections as a risk factor for non-neoplastic portal vein thrombosis development in cirrhotic patients «Digestive Liver Disease» , vol. 56 , n. 3 , 2024 , pp. 477-483

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