Publications

Authors:

Costantini, Ilaria; Mantelli, Giovanni; Carollo, Massimo; Losso, Lorenzo; Morando, Elia; Bacchion, Matilde; Castri, Mariapaola; Drezza, Lucia; Ricci, Giorgio

Title:

Not only Van Gogh: a case of BRASH syndrome with concomitant digoxin toxicity

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF MEDICAL CASE REPORTS

ISSN of journal:

1752-1947

N° Volume:

18

Number or Folder:

1

Page numbers:

N/A-N/A

Keyword:

BRASH syndrome; Bradycardia; Case report; Digoxin toxicity; Hyperkalemia

Short description of contents:

Background Bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia syndrome is a potentially life-threatening clinical condition characterized by bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia. It constitutes a vicious circle in which the accumulation of pharmacologically active compounds and hyperkalemia lead to hemodynamic instability and heart failure.Case presentation A 66-year-old Caucasian female patient was admitted to the emergency department presenting with fatigue and bradycardia. Upon examination, the patient was found to be anuric and hypotensive. Laboratory investigations revealed metabolic acidosis and hyperkalemia. Clinical evaluation suggested signs of digoxin toxicity, with serum digoxin concentrations persistently elevated over several days. Despite the implementation of antikalemic measures, the patient's condition remained refractory, necessitating renal dialysis and administration of digoxin immune fab.Conclusion Bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia syndrome is a life-threatening condition that requires prompt management. It is important to also consider potential coexisting clinical manifestations indicative of intoxication from other pharmacological agents. Specifically, symptoms associated with the accumulation of drugs eliminated via the kidneys, such as digoxin. These manifestations may warrant targeted therapeutic measures.

Product ID:

140303

Handle IRIS:

11562/1129747

Last Modified:

June 29, 2024

Bibliographic citation:

Costantini, Ilaria; Mantelli, Giovanni; Carollo, Massimo; Losso, Lorenzo; Morando, Elia; Bacchion, Matilde; Castri, Mariapaola; Drezza, Lucia; Ricci, Giorgio, Not only Van Gogh: a case of BRASH syndrome with concomitant digoxin toxicity «JOURNAL OF MEDICAL CASE REPORTS» , vol. 18 , n. 1 , 2024 , pp. N/A-N/A

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