Publications

Authors:

Caminati, Marco; Marcon, Alessandro; Vaia, Rachele; Senna, Gianenrico; Maule, Matteo; Marchetti, Pierpaolo; Miotti, Jessica; Argentino, Giuseppe; Blasi, Francesco; Canonica, Giorgio W; Heffler, Enrico M; Paggiaro, Pierluigi; Vianello, Andrea; Guarnieri, Gabriella

Title:

Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

THE WORLD ALLERGY ORGANIZATION JOURNAL

ISSN of journal:

1939-4551

N° Volume:

17

Number or Folder:

8

Page numbers:

1-14

Keyword:

Aging; Asthma control; Comorbidities; Lung function; Severe asthma

Short description of contents:

Background: Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to a more difficult disease control in different age groups. Methods: Patients from Severe Asthma Network Italy (SANI) registry were retrospectively divided in subgroups according to their age. Cutoffs for age were established according to quartiles in order to obtain a comparable number of patients for each group, and then rounded for the sake of simplicity. Results: Overall, 1805 severe asthma patients were analyzed. Lung function represented the most important age-related variable. On the opposite the level of asthma control was not differently distributed among age ranges. In young people the presence of atopy-related comorbidities (allergic rhinitis, atopic dermatitis) predominated, whilst systemic-metabolic and degenerative comorbidities such as diabetes, cardiovascular diseases, anxious-depressive syndrome, and osteoporosis prevailed in elderly. Bronchiectasis and sleep disturbances were significantly associated with age. Conclusions: Despite that it cannot be considered a treatable trait, our study suggests that age should be evaluated within a personalized approach to severe asthma patients, in order to provide a better clinical profiling and a more tailored treatment strategy.

Product ID:

140858

Handle IRIS:

11562/1134168

Last Modified:

January 30, 2025

Bibliographic citation:

Caminati, Marco; Marcon, Alessandro; Vaia, Rachele; Senna, Gianenrico; Maule, Matteo; Marchetti, Pierpaolo; Miotti, Jessica; Argentino, Giuseppe; Blasi, Francesco; Canonica, Giorgio W; Heffler, Enrico M; Paggiaro, Pierluigi; Vianello, Andrea; Guarnieri, Gabriella, Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort «THE WORLD ALLERGY ORGANIZATION JOURNAL» , vol. 17 , n. 8 , 2024 , pp. 1-14

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