Publications

Authors:

Mantovani, Alessandro; Morandin, Riccardo; Fiorio, Veronica; Lando, Maria Giovanna; Petta, Salvatore; Ferraro, Pietro Manuel; Targher, Giovanni

Title:

Association between metabolic dysfunction-associated steatotic liver disease and risk of urolithiasis: an updated systematic review and meta-analysis

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

INTERNAL AND EMERGENCY MEDICINE

ISSN of journal:

1828-0447

N° Volume:

19

Number or Folder:

6

Page numbers:

1745-1755

Keyword:

MASLD; Meta-analysis; Metabolic dysfunction-associated steatotic liver disease; NAFLD; Nonalcoholic fatty liver disease; Renal stones; Urolithiasis

Short description of contents:

Epidemiological studies have reported an association between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of urolithiasis. However, the magnitude of the risk and whether this risk varies with the severity of MASLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between MASLD and urolithiasis. We systematically searched PubMed, Scopus, and Web of Science from database inception to March 31, 2024, using predefined keywords to identify relevant observational studies in which imaging methods or survey questionnaires diagnosed MASLD and urolithiasis. Meta-analysis was performed using random-effects modelling. We identified seven cross-sectional studies and one prospective cohort study with aggregate data on 248,936 adults from different countries. MASLD was significantly associated with an increased risk of prevalent urolithiasis (pooled random-effects odds ratio 1.87, 95% CI 1.34-2.60; I2 = 91%). This association remained significant in those studies whose results were adjusted for age, sex, ethnicity, obesity, diabetes, and other potential confounders. There was a positive graded association between the ultrasonographic severity of MASLD and urolithiasis. Meta-analysis of the single prospective cohort study showed that MAFLD was not associated with risk of developing incident urolithiasis (pooled random-effects hazard ratio 1.08, 95% CI 0.90-1.30), although a significant association was reported in men. Sensitivity analyses did not modify these findings. The funnel plot did not reveal any significant publication bias. This updated meta-analysis provides evidence for a significant association between MASLD and the presence of urolithiasis. Whether MASLD is associated with a higher risk of developing incident urolithiasis remains to be established.

Product ID:

141352

Handle IRIS:

11562/1139186

Last Modified:

October 27, 2024

Bibliographic citation:

Mantovani, Alessandro; Morandin, Riccardo; Fiorio, Veronica; Lando, Maria Giovanna; Petta, Salvatore; Ferraro, Pietro Manuel; Targher, Giovanni, Association between metabolic dysfunction-associated steatotic liver disease and risk of urolithiasis: an updated systematic review and meta-analysis «INTERNAL AND EMERGENCY MEDICINE» , vol. 19 , n. 6 , 2024 , pp. 1745-1755

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