Publications

Authors:

Biasi, Domenico; Bambara, Lisa Maria; Carletto, Antonio; Caramaschi, Paola; Ortolani, Riccardo; Perona, Giuseppe; Bellavite, Paolo

Title:

Increased in vitro neutrophil adherence in a case of chronic idiopathic neutropenia

Year:

1994

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

British Journal of Haematology

ISSN of journal:

0007-1048

N° Volume:

86

Page numbers:

421-4

Keyword:

Neutropenia; Adhesion; Haematology

Short description of contents:

In this report we describe a patient with persistent neutropenia whose neutrophils showed increased adhesion in a microplate assay. In three separate assays, from 12.5% to 13.7% of the patient's blood neutrophils exhibited spontaneous (unstimulated) adhesion to fetal bovine serum-coated microplate wells, much higher than adhesion of cells from healthy controls (1.9% +/- 2.5 SD, n = 20). The difference of spontaneous adhesion between the patient's and control neutrophils was even higher when cells from a skin-window exudate were examined (patient: 42.1-100% adhesion; control: 3.6% +/- 3.5 SD, n = 20). Over 80% inhibition of the increased adhesion was produced by the 60.3 anti-CD 18 monoclonal antibody, suggesting an involvement of beta 2-integrins.

Product ID:

1141

Handle IRIS:

11562/1141

Deposited On:

May 5, 2010

Last Modified:

November 3, 2022

Bibliographic citation:

Biasi, Domenico; Bambara, Lisa Maria; Carletto, Antonio; Caramaschi, Paola; Ortolani, Riccardo; Perona, Giuseppe; Bellavite, Paolo, Increased in vitro neutrophil adherence in a case of chronic idiopathic neutropenia «British Journal of Haematology» , vol. 86 , 1994 , pp. 421-4

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