Publications

Authors:

Zhou, Xiao-Dong; Kim, Seung Up; Yip, Terry Cheuk-Fung; Petta, Salvatore; Nakajima, Atsushi; Tsochatzis, Emmanuel; Boursier, Jérôme; Bugianesi, Elisabetta; Hagström, Hannes; Chan, Wah Kheong; Romero-Gomez, Manuel; Calleja, José Luis; de Lédinghen, Victor; Castéra, Laurent; Sanyal, Arun J; Goh, George Boon-Bee; Newsome, Philip N; Fan, Jiangao; Lai, Michelle; Fournier-Poizat, Céline; Lee, Hye Won; Wong, Grace Lai-Hung; Armandi, Angelo; Shang, Ying; Pennisi, Grazia; Llop, Elba; Yoneda, Masato; Saint-Loup, Marc de; Canivet, Clemence M; Lara-Romero, Carmen; Gallego-Duràn, Rocio; Asgharpour, Amon; Teh, Kevin Kim-Jun; Mahgoub, Sara; Chan, Mandy Sau-Wai; Lin, Huapeng; Liu, Wen-Yue; Targher, Giovanni; Byrne, Christopher D; Wong, Vincent Wai-Sun; Zheng, Ming-Hua

Title:

Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Gut

ISSN of journal:

0017-5749

N° Volume:

73

Number or Folder:

11

Page numbers:

1883-1892

Keyword:

FATTY LIVER; FIBROSIS; STATINS; LIVER-RELATED EVENTS; FIBROSIS PROGRESSION; MASLD; MASH

Short description of contents:

Background Statins have multiple benefits in patients with metabolic-associated steatotic liver disease (MASLD). Aim To explore the effects of statins on the long-term risk of all-cause mortality, liver-related clinical events (LREs) and liver stiffness progression in patients with MASLD. Methods This cohort study collected data on patients with MASLD undergoing at least two vibration-controlled transient elastography examinations at 16 tertiary referral centres. Cox regression analysis was performed to examine the association between statin usage and long-term risk of all-cause mortality and LREs stratified by compensated advanced chronic liver disease (cACLD): baseline liver stiffness measurement (LSM) of >= 10 kPa. Liver stiffness progression was defined as an LSM increase of >= 20% for cACLD and from <10 kPa to >= 10 or LSM for non-cACLD. Liver stiffness regression was defined as LSM reduction from >= 10 kPa to <10 or LSM decrease of >= 20% for cACLD. Results We followed up 7988 patients with baseline LSM 5.9 kPa (IQR 4.6-8.2) for a median of 4.6 years. At baseline, 40.5% of patients used statins, and cACLD was present in 17%. Statin usage was significantly associated with a lower risk of all-cause mortality (adjusted HR=0.233; 95% CI 0.127 to 0.426) and LREs (adjusted HR=0.380; 95% CI 0.268 to 0.539). Statin usage was also associated with lower liver stiffness progression rates in cACLD (HR=0.542; 95% CI 0.389 to 0.755) and non-cACLD (adjusted HR=0.450; 95% CI 0.342 to 0.592), but not with liver stiffness regression (adjusted HR=0.914; 95% CI 0.778 to 1.074). Conclusions Statin usage was associated with a relatively lower long-term risk of all-cause mortality, LREs and liver stiffness progression in patients with MASLD.

Product ID:

141981

Handle IRIS:

11562/1143991

Last Modified:

October 30, 2024

Bibliographic citation:

Zhou, Xiao-Dong; Kim, Seung Up; Yip, Terry Cheuk-Fung; Petta, Salvatore; Nakajima, Atsushi; Tsochatzis, Emmanuel; Boursier, Jérôme; Bugianesi, Elisabetta; Hagström, Hannes; Chan, Wah Kheong; Romero-Gomez, Manuel; Calleja, José Luis; de Lédinghen, Victor; Castéra, Laurent; Sanyal, Arun J; Goh, George Boon-Bee; Newsome, Philip N; Fan, Jiangao; Lai, Michelle; Fournier-Poizat, Céline; Lee, Hye Won; Wong, Grace Lai-Hung; Armandi, Angelo; Shang, Ying; Pennisi, Grazia; Llop, Elba; Yoneda, Masato; Saint-Loup, Marc de; Canivet, Clemence M; Lara-Romero, Carmen; Gallego-Duràn, Rocio; Asgharpour, Amon; Teh, Kevin Kim-Jun; Mahgoub, Sara; Chan, Mandy Sau-Wai; Lin, Huapeng; Liu, Wen-Yue; Targher, Giovanni; Byrne, Christopher D; Wong, Vincent Wai-Sun; Zheng, Ming-Hua, Long-term liver-related outcomes and liver stiffness progression of statin usage in steatotic liver disease «Gut» , vol. 73 , n. 11 , 2024 , pp. 1883-1892

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