Pubblicazioni

Autori:

Gian Paolo, Fadini; Enrico, Longato; Mario Luca, Morieri; Stefano, Del Prato; Angelo, Avogaro; Anna, Solini; Baldassarre, Mariella; Consoli, Agostino; Morganet, Sara; Zugaro, Antonella; Giorgio Baroni, Marco; Andreozzi, Francesco; Gatti, Adriano; Gatti, Adriano; De Riu, Stefano; Del Buono, Andrea; Aldigeri, Raffaella; Bonadonna, Riccardo; Dei Cas, Alessandra; Vazzana, Angela; Antonini, Monica; Moretti, Valentina; Li Volsi, Patrizia; Cesare, Miranda; Zanette, Giorgio; Carletti, Silvia; D'Angelo, Paola; Leto, Gaetano; Leonetti, Frida; D'Onofrio, Luca; Maddaloni, Ernesto; Buzzetti, Raffaella; Frontoni, Simona; Cavallo, Giselle; Morano, Susanna; Filardi, Tiziana; Capece, Umberto; Giaccari, Andrea; C Bossi, Antonio; Meregalli, Giancarla; Querci, Fabrizio; Gaglio, Alessia; Resi, Veronica; Orsi, Emanuela; Fazion, Stefano; G Franzetti, Ivano; Berra, Cesare; Manfrini, Silvia; Garrapa, Gabriella; Lucarelli, Giulio; Riccialdelli, Lara; Tortato, Elena; Zavattaro, Marco; Aimaretti, Gianluca; Cavalot, Franco; Beccuti, Guglielmo; Broglio, Fabio; Fattor, Bruno; Cazzetta, Giuliana; Lamacchia, Olga; Rauseo, Anna; De Cosmo, Salvatore; Cau, Rosella; Ghiani, Mariangela; Di Benedetto, Antonino; Di Pino, Antonino; Piro, Salvatore; Purrello, Francesco; Frittitta, Lucia; Milluzzo, Agostino; Russo, Giuseppina

Titolo:

Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

THE LANCET REGIONAL HEALTH. EUROPE

ISSN Rivista:

2666-7762

N° Volume:

38

Intervallo pagine:

1-14

Parole chiave:

Chronic kidney disease; Observational; Prevention; SGLT2 inhibitors; Type 2 diabetes

Breve descrizione dei contenuti:

Background: Despite the overall improvement in care, people with type 2 diabetes (T2D) experience an excess risk of end-stage kidney disease. We evaluated the long-term effectiveness of dapagliflozin on kidney function and albuminuria in patients with T2D. Methods: We included patients with T2D who initiated dapagliflozin or comparators from 2015 to 2020. Propensity score matching (PSM) was performed to balance the two groups. The primary endpoint was the change in estimated glomerular filtration rate (eGFR) from baseline to the end of observation. Secondary endpoints included changes in albuminuria and loss of kidney function. Findings: We analysed two matched groups of 6197 patients each. The comparator group included DPP-4 inhibitors (40%), GLP-1RA (22.3%), sulphonylureas (16.1%), pioglitazone (8%), metformin (5.8%), or acarbose (4%). Only 6.4% had baseline eGFR <60 ml/min/1.73 m2 and 15% had UACR >30 mg/g. During a mean follow-up of 2.5 year, eGFR declined significantly less in the dapagliflozin vs comparator group by 1.81 ml/min/1.73 m2 (95% C.I. from 1.13 to 2.48; p < 0.0001). The mean eGFR slope was significantly less negative in the dapagliflozin group by 0.67 ml/min/1.73 m2/year (95% C.I. from 0.47 to 0.88; p < 0.0001). Albuminuria declined significantly in new-users of dapagliflozin within 6 months and remained on average 44.3 mg/g lower (95% C.I. from -66.9 to -21.7; p < 0.0001) than in new-users of comparators. New-users of dapagliflozin had significantly lower rates of new-onset CKD, loss of kidney function, and a composite renal outcome. Results were confirmed for all SGLT2 inhibitors, in patients without baseline CKD, and when GLP-1RA were excluded from comparators. Interpretation: Initiating dapagliflozin improved kidney function outcomes and albuminuria in patients with T2D and a low renal risk. Funding: Funded by the Italian Diabetes Society and partly supported by a grant from AstraZeneca.

Id prodotto:

142213

Handle IRIS:

11562/1144400

ultima modifica:

1 novembre 2024

Citazione bibliografica:

Gian Paolo, Fadini; Enrico, Longato; Mario Luca, Morieri; Stefano, Del Prato; Angelo, Avogaro; Anna, Solini; Baldassarre, Mariella; Consoli, Agostino; Morganet, Sara; Zugaro, Antonella; Giorgio Baroni, Marco; Andreozzi, Francesco; Gatti, Adriano; Gatti, Adriano; De Riu, Stefano; Del Buono, Andrea; Aldigeri, Raffaella; Bonadonna, Riccardo; Dei Cas, Alessandra; Vazzana, Angela; Antonini, Monica; Moretti, Valentina; Li Volsi, Patrizia; Cesare, Miranda; Zanette, Giorgio; Carletti, Silvia; D'Angelo, Paola; Leto, Gaetano; Leonetti, Frida; D'Onofrio, Luca; Maddaloni, Ernesto; Buzzetti, Raffaella; Frontoni, Simona; Cavallo, Giselle; Morano, Susanna; Filardi, Tiziana; Capece, Umberto; Giaccari, Andrea; C Bossi, Antonio; Meregalli, Giancarla; Querci, Fabrizio; Gaglio, Alessia; Resi, Veronica; Orsi, Emanuela; Fazion, Stefano; G Franzetti, Ivano; Berra, Cesare; Manfrini, Silvia; Garrapa, Gabriella; Lucarelli, Giulio; Riccialdelli, Lara; Tortato, Elena; Zavattaro, Marco; Aimaretti, Gianluca; Cavalot, Franco; Beccuti, Guglielmo; Broglio, Fabio; Fattor, Bruno; Cazzetta, Giuliana; Lamacchia, Olga; Rauseo, Anna; De Cosmo, Salvatore; Cau, Rosella; Ghiani, Mariangela; Di Benedetto, Antonino; Di Pino, Antonino; Piro, Salvatore; Purrello, Francesco; Frittitta, Lucia; Milluzzo, Agostino; Russo, Giuseppina, Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk «THE LANCET REGIONAL HEALTH. EUROPE» , vol. 38 , 2024 , pp. 1-14

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo