Pubblicazioni

Autori:

Canè, Stefania; Geiger, Roger; Bronte, Vincenzo

Titolo:

The roles of arginases and arginine in immunity

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

NATURE REVIEWS IMMUNOLOGY

ISSN Rivista:

1474-1733

Intervallo pagine:

123-135

Parole chiave:

immunology, arginase, arginine, cancer, autoimmune diseases, infectious diseases

Breve descrizione dei contenuti:

Arginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysregulation is commonly observed in cancer, autoimmune disorders and infectious diseases. Following the initial description of a role for arginase in the dysfunction of T cells mounting an antitumour response, numerous studies have broadened our understanding of the regulation and expression of arginases and their integration with other metabolic pathways. Here, we highlight the differences in arginase compartmentalization and storage between humans and rodents that should be taken into consideration when assessing the effects of arginase activity. We detail the roles of arginases, arginine and its metabolites in immune cells and their effects in the context of cancer, autoimmunity and infectious disease. Finally, we explore potential therapeutic strategies targeting arginases and arginine.This Review provides an overview of arginine and arginase function in immune cells, at the steady state and during disease. It considers the relevance of this pathway for metabolic, immune and genetic regulation, together with possible therapeutic interventions.

Id prodotto:

142620

Handle IRIS:

11562/1145266

ultima modifica:

20 dicembre 2024

Citazione bibliografica:

Canè, Stefania; Geiger, Roger; Bronte, Vincenzo, The roles of arginases and arginine in immunity «NATURE REVIEWS IMMUNOLOGY» , 2024 , pp. 123-135

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo