Publications

Authors:

Canè, Stefania; Geiger, Roger; Bronte, Vincenzo

Title:

The roles of arginases and arginine in immunity

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

NATURE REVIEWS IMMUNOLOGY

ISSN of journal:

1474-1733

Page numbers:

123-135

Keyword:

immunology, arginase, arginine, cancer, autoimmune diseases, infectious diseases

Short description of contents:

Arginase activity and arginine metabolism in immune cells have important consequences for health and disease. Their dysregulation is commonly observed in cancer, autoimmune disorders and infectious diseases. Following the initial description of a role for arginase in the dysfunction of T cells mounting an antitumour response, numerous studies have broadened our understanding of the regulation and expression of arginases and their integration with other metabolic pathways. Here, we highlight the differences in arginase compartmentalization and storage between humans and rodents that should be taken into consideration when assessing the effects of arginase activity. We detail the roles of arginases, arginine and its metabolites in immune cells and their effects in the context of cancer, autoimmunity and infectious disease. Finally, we explore potential therapeutic strategies targeting arginases and arginine.This Review provides an overview of arginine and arginase function in immune cells, at the steady state and during disease. It considers the relevance of this pathway for metabolic, immune and genetic regulation, together with possible therapeutic interventions.

Product ID:

142620

Handle IRIS:

11562/1145266

Last Modified:

December 20, 2024

Bibliographic citation:

Canè, Stefania; Geiger, Roger; Bronte, Vincenzo, The roles of arginases and arginine in immunity «NATURE REVIEWS IMMUNOLOGY» , 2024 , pp. 123-135

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