Hidradenitis suppurativa is a chronic inflammatory disease of the skin with a suppurative-cicatricial outcome affecting the
infundibular component of the pilo-sebaceous unit. The lesions are typically localized in the intertriginous and apocrine
gland-rich areas. Hidradenitis suppurativa mainly affects patients at a young age and is very often refractory to conventional
medical treatment. During pregnancy, the management of hidradenitis suppurativa becomes demanding due to the need of
safety therapies. Certolizumab pegol is a pegylated monoclonal TNF-α inhibitor that lacks the fragment crystallizable region
preventing active placental transfer and could be used in pregnancy and lactation if clinically needed and is label for chronic
plaque psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease. Herein, we describe a case
of a 32-year-old pregnant woman with Hurley stage III hidradenitis suppurativa successfully treated with certolizumab pegol.