Publications

Authors:

Feng, Gong; Yilmaz, Yusuf; Valenti, Luca; Seto, Wai-Kay; Pan, Calvin Q; Méndez-Sánchez, Nahum; Ye, Feng; Sookoian, Silvia; Targher, Giovanni; Byrne, Christopher D; Chan, Wah-Kheong; Treeprasertsuk, Sombat; Yu, Hon Ho; Kim, Seung Up; George, Jacob; Xu, Wen-Jing; Sebastiani, Giada; Ocama, Ponsiano; Ryan, John D; Lupșor-Platon, Monica; Ghazinyan, Hasmik; Hamid, Saeed; Perera, Nilanka; Alswat, Khalid; Isakov, Vasily; Pan, Qiuwei; Sarin, Shiv Kumar; Schattenberg, Jörn M; Sotoudeheian, Mohammadjavad; Wong, Yu Jun; Sharara, Ala I; Al-Busafi, Said A; Opio, Christopher Kenneth; Chai, Jin; Fouad, Yasser; Shi, Yu; Al-Mahtab, Mamun; Zhang, Sujuan; Pirola, Carlos Jose; Wong, Vincent Wai-Sun; Zheng, Ming-Hua

Title:

Global Burden of Major Chronic Liver Diseases in 2021

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

LIVER INTERNATIONAL

ISSN of journal:

1478-3223

N° Volume:

45

Number or Folder:

4

Page numbers:

70058-70069

Keyword:

MASLD; Viral hepatitis; alcohol-related diseases

Short description of contents:

Background: This study utilised the Global Burden of Disease data (2010-2021) to analyse the rates and trends in point prevalence, annual incidence and years lived with disability (YLDs) for major chronic liver diseases, such as hepatitis B, hepatitis C, metabolic dysfunction-associated liver disease, cirrhosis and other chronic liver diseases. Methods: Age-standardised rates per 100,000 population for prevalence, annual incidence and YLDs were compared across regions and countries, as well as the socio-demographic index (SDI). Trends were expressed as percentage changes (PC) and estimates were reported with uncertainty intervals (UI). Results: Globally, in 2021, the age-standardised rates per 100,000 population for the prevalence of hepatitis B, hepatitis C, MASLD and cirrhosis and other chronic liver diseases were 3583.6 (95%UI 3293.6-3887.7), 1717.8 (1385.5-2075.3), 15018.1 (13756.5-16361.4) and 20302.6 (18845.2-21791.9) respectively. From 2010 to 2021, the PC in age-standardised prevalence rates were-20.4% for hepatitis B, -5.1% for hepatitis C, +11.2% for MASLD and + 2.6% for cirrhosis and other chronic liver diseases. Over the same period, the PC in age-standardized incidence rates were -24.7%, -6.8%, +3.2%, and +3.0%, respectively. Generally, negative associations, but with fluctuations, were found between age-standardised prevalence rates for hepatitis B, hepatitis C, cirrhosis and other chronic liver diseases and the SDI at a global level. However, MASLD prevalence peaked at moderate SDI levels. Conclusions: The global burden of chronic liver diseases remains substantial. Hepatitis B and C have decreased in prevalence and incidence in the last decade, while MASLD, cirrhosis and other chronic liver diseases have increased, necessitating targeted public health strategies and resource allocation.

Product ID:

145276

Handle IRIS:

11562/1160181

Last Modified:

April 19, 2025

Bibliographic citation:

Feng, Gong; Yilmaz, Yusuf; Valenti, Luca; Seto, Wai-Kay; Pan, Calvin Q; Méndez-Sánchez, Nahum; Ye, Feng; Sookoian, Silvia; Targher, Giovanni; Byrne, Christopher D; Chan, Wah-Kheong; Treeprasertsuk, Sombat; Yu, Hon Ho; Kim, Seung Up; George, Jacob; Xu, Wen-Jing; Sebastiani, Giada; Ocama, Ponsiano; Ryan, John D; Lupșor-Platon, Monica; Ghazinyan, Hasmik; Hamid, Saeed; Perera, Nilanka; Alswat, Khalid; Isakov, Vasily; Pan, Qiuwei; Sarin, Shiv Kumar; Schattenberg, Jörn M; Sotoudeheian, Mohammadjavad; Wong, Yu Jun; Sharara, Ala I; Al-Busafi, Said A; Opio, Christopher Kenneth; Chai, Jin; Fouad, Yasser; Shi, Yu; Al-Mahtab, Mamun; Zhang, Sujuan; Pirola, Carlos Jose; Wong, Vincent Wai-Sun; Zheng, Ming-Hua, Global Burden of Major Chronic Liver Diseases in 2021 «LIVER INTERNATIONAL» , vol. 45 , n. 4 , 2025 , pp. 70058-70069

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo