Publications

Authors:

Sartorio, Andrea; Cristin, Luca; Pont, Chiara Dal; Farzaneh-Far, Afshin; Romano, Simone

Title:

Global longitudinal strain as an early marker of cardiac damage after cardiotoxic medications, a state of the art review

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Progress in Cardiovascular Diseases

ISSN of journal:

0033-0620

Page numbers:

1-3

Keyword:

Cardiotoxicity; Drugs; Ejection fraction; Global longitudinal strain

Short description of contents:

: Ejection fraction (EF) is the principal parameter used clinically to assess cardiac function and provides prognostic information. However, significant myocardial damage can be present despite preserved EF. Recently, the measurement of left ventricle (LV) deformation by global longitudinal strain (GLS) has been introduced as a novel early marker of cardiac dysfunction. Cardiotoxicity is a frequent side effect of several drugs most notably those used in the treatment of cancer. Although oncology drugs remain the best known cardiotoxic medications, many other drugs can potentially affect LV function. The early recognition of LV dysfunction due to cardiotoxicity is important and of increasing clinical relevance particularly with the rapid pace of development of new drugs. The aim of our review is to provide an overview of the current literature regarding utility of GLS to assess drug-induced myocardial damage. We propose that GLS is a sensitive early marker of myocardial dysfunction associated with the use of certain medications with high risk of cardiotoxicity. Thus, the use of this technique can potentially alert the clinician to myocardial toxicity before reductions in EF are seen.

Product ID:

145428

Handle IRIS:

11562/1160955

Last Modified:

May 2, 2025

Bibliographic citation:

Sartorio, Andrea; Cristin, Luca; Pont, Chiara Dal; Farzaneh-Far, Afshin; Romano, Simone, Global longitudinal strain as an early marker of cardiac damage after cardiotoxic medications, a state of the art review «Progress in Cardiovascular Diseases» , 2025 , pp. 1-3

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