Publications

Authors:

Pollastri, Francesco; Fassio, Angelo; Ferraro, Pietro Manuel; Andreola, Stefano; Gambaro, Giovanni; Spasiano, Andrea; Caletti, Chiara; Stefani, Lisa; Gatti, Matteo; Fabbrini, Paolo; Rossini, Maurizio; Galvagni, Isotta; Gatti, Davide; Adami, Giovanni; Viapiana, Ombretta

Title:

Long-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated with Denosumab

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Calcified Tissue International

ISSN of journal:

0171-967X

N° Volume:

116

Number or Folder:

1

Page numbers:

42-43

Keyword:

3D-DXA; DXA; Denosumab; Indices of bone quality; Kidney transplant recipients; TBS

Short description of contents:

Kidney transplant recipients (KTRs) have an elevated fracture risk. While dual-energy X-ray absorptiometry (DXA) is commonly used to assess areal bone mineral density (aBMD), it does not capture all aspects of bone quality. We investigated the long-term effects on bone DXA-derived indices of bone quality in KTRs treated with denosumab and untreated with denosumab. This is a retrospective study, including KTRs treated with denosumab and untreated age and sex-matched KTR controls. DXA-derived parameters, including trabecular bone score (TBS) and 3D-DXA parameters, were measured at the lumbar spine and femur at baseline and after four years. Hierarchical linear models were used to assess the between-group effect of treatment over time, also adjusting for site-specific aBMDs. We enrolled 23 KTRs treated with denosumab and 23 KTR denosumab-untreated KTRs. Significant between-group differences over time in favor of the denosumab group were observed for TBS (0.843, 95%CI 0.439; 1.248,p < 0.001), trabecular volumetric BMD at the total hip (Tb.vBMD TH) (13.492, 95%CI 1.707; 25.278, p = 0.003), cortical volumetric BMD at the femoral neck (Ct.vBMD FN) (28.766, 95%CI 8.373; 49.158, p = 0.008), cortical surface BMD at the total hip (c.sBMD TH) (10.507, 95%CI 4.140; 16.873,p = 0.002), cortical surface at the femoral neck (c.sBMD FN) (8.795, 95%CI 2.818; 14.771, p = 0.006), and cortical thickness at the total hip (Ct.th.TH) (0.075, 95%CI 0.020; 0.130, p = 0.010). After adjusting for BMD, the differences on TBS and Ct.vBMD FN and c.sBMD FN remained significant. Denosumab treatment in KTRs was associated with better outcomes in terms of bone quality and geometry parameters, independent of changes in aBMD.

Product ID:

145492

Handle IRIS:

11562/1161274

Last Modified:

May 7, 2025

Bibliographic citation:

Pollastri, Francesco; Fassio, Angelo; Ferraro, Pietro Manuel; Andreola, Stefano; Gambaro, Giovanni; Spasiano, Andrea; Caletti, Chiara; Stefani, Lisa; Gatti, Matteo; Fabbrini, Paolo; Rossini, Maurizio; Galvagni, Isotta; Gatti, Davide; Adami, Giovanni; Viapiana, Ombretta, Long-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated with Denosumab «Calcified Tissue International» , vol. 116 , n. 1 , 2025 , pp. 42-43

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