Pubblicazioni

Autori:

Sota, Jurgen; Ragab, Gaafar; Almaglouth, Ibrahim; Lopalco, Giuseppe; Tufan, Abdurrahman; Direskeneli, Haner; Hinojosa-Azaola, Andrea; Mayrink Giardini, Henrique Ayres; Guerriero, Silvana; Triggianese, Paola; Sfikakis, Petros P; Piga, Matteo; Ruscitti, Piero; Govoni, Marcello; Iagnocco, Annamaria; Carubbi, Francesco; Hernández-Rodríguez, José; Laymouna, Ahmed Hatem; Mahmoud, Ayman Abdel-Monem Ahmed; Ghanema, Mahmoud; Aboabat, Aos A; Asfina, Kazi Nur; Alanazi, Fehaid; Morrone, Maria; Spedicato, Veronica; Kucuk, Hamit; Kardas, Riza; Alibaz Öner, Fatma; Sevik, Gizem; Torres-Ruiz, Jiram; Kawakami-Campos, Perla Ayumi; Parente de Brito Antonelli, Isabelle; Dammacco, Rosanna; Chimenti, Maria Sole; Arida, Katerina; Floris, Alberto; Gentile, Martina; Ruffilli, Francesca; Bellis, Elisa; Alunno, Alessia; Espinosa, Gerard; Gentileschi, Stefano; Gaggiano, Carla; Vitale, Antonio; Caggiano, Valeria; Lopez, Roberta; Tarsia, Maria; Monti, Sara; Hatemi, Gülen; Karakoç, Alican; Frassi, Micol; Giacomelli, Roberto; Tharwat, Samar; Thabet, Maissa; Ciccia, Francesco; Emmi, Giacomo; Viapiana, Ombretta; Şahin, Ali; Sebastiani, Gian Domenico; Batu, Ezgi Deniz; Ozen, Seza; Sener, Seher; Opris-Belinski, Daniela; Costi, Stefania; Conforti, Alessandro; Cattalini, Marco; Bartoloni, Elena; Akkoç, Nurullah; Gunduz, Ozgul Soysal; Conti, Giovanni; Maier, Armin; Giardina, Annarita; Li Gobbi, Francesca; Parronchi, Paola; Sarzi Puttini, Piercarlo; Breda, Luciana; De Paulis, Amato; Carreño, Ester; La Torre, Francesco; Więsik-Scewczyk, Ewa; de-la Torre, Alejandra; Mejía-Salgado, Germán; Shahram, Farhad; Guiducci, Serena; Maggio, Maria Cristina; Aragona, Emma; Rigante, Donato; Ciavarro, Alessandro; Önen, Fatos; Erten, Şükran; Insalaco, Antonella; Del Giudice, Emanuela; Barone, Patrizia; Gicchino, Francesca; Brucato, Antonio; Lo Gullo, Alberto; Mauro, Angela; Karamanakos, Anastasios; Balistreri, Alberto; Mazzei, Maria Antonietta; Frediani, Bruno; Fabiani, Claudia; Cantarini, Luca

Titolo:

Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

JOINT BONE SPINE

ISSN Rivista:

1297-319X

N° Volume:

92

Numero o Fascicolo:

2

Editore:

Editions scientifiques Medicales Elsevier

Intervallo pagine:

1-5

Parole chiave:

Autoinflammatory; Behçet's disease; Gender; Organ damage; Registry

Breve descrizione dei contenuti:

Objectives. - Gender impact on phenotypical expression of Behcet's disease (BD) has been specifically investigated only in a few large-scale studies. The main goal of the study was to examine gender differences in a large cohort of patients affected by BD.Methods. - Data were retrieved from the International AIDA Network Registry for BD. We assessed differences between males and females in terms of Behcet's syndrome Overall Damage Index (BODI), differences in the disease manifestations at onset and in the cumulative manifestations throughout diseasecourse, as well as differences in the cardiovascular risk. Finally, predictive factors leading to major organ involvement were investigated.Results. - In total, 1024 BD patients (567 males, 457 females) were enrolled in the study, with a male-to-female ratio of 1.24/1. Males displayed a significantly higher mean +/- SD BODI (1.92 +/- 2.09) at the last follow-up, compared to female patients (1.25 +/- 1.87) (P < 0.0001). Uveitis (P < 0.0001) and vascular involvement (P = 0.0076) were significantly more frequent among males whereas female patients were significantly over-represented in arthralgia (P < 0.0001), arthritis (P = 0.00025), isolated headache (P < 0.0001), central nervous system (CNS) involvement (P = 0.040), and gastrointestinal involvement (P = 0.00046). Regarding cardiovascular risk, no differences between the two groups emerged (P = 0.617). Four variables were associated with the development of major organ involvement: male gender (OR = 2.104, P = 0.001), current treatment with biologic agents (OR = 2.257, P = 0.0003), origin from endemic countries (OR = 2.661, P = 0.0009), and disease duration (OR = 1.002, P = 0.024).Conclusion. - BD displays a more severe course among males. This subgroup develops more irreversible damage and presents more frequently ocular and vascular involvement during disease course. On the other hand, female patients are prone to experience articular involvement, headache, CNS and gastrointestinal involvement. These data suggest the existence of a gender-driven disease expression. (c) 2024 Les Auteurs. Publie par Elsevier Masson SAS au nom de Socioto Franoaise de Rhumatologie. Cet article est publie en Open Access sous licence CC BY (http://creativecommons.org/licenses/by/4.0/).

Id prodotto:

145538

Handle IRIS:

11562/1161357

ultima modifica:

8 maggio 2025

Citazione bibliografica:

Sota, Jurgen; Ragab, Gaafar; Almaglouth, Ibrahim; Lopalco, Giuseppe; Tufan, Abdurrahman; Direskeneli, Haner; Hinojosa-Azaola, Andrea; Mayrink Giardini, Henrique Ayres; Guerriero, Silvana; Triggianese, Paola; Sfikakis, Petros P; Piga, Matteo; Ruscitti, Piero; Govoni, Marcello; Iagnocco, Annamaria; Carubbi, Francesco; Hernández-Rodríguez, José; Laymouna, Ahmed Hatem; Mahmoud, Ayman Abdel-Monem Ahmed; Ghanema, Mahmoud; Aboabat, Aos A; Asfina, Kazi Nur; Alanazi, Fehaid; Morrone, Maria; Spedicato, Veronica; Kucuk, Hamit; Kardas, Riza; Alibaz Öner, Fatma; Sevik, Gizem; Torres-Ruiz, Jiram; Kawakami-Campos, Perla Ayumi; Parente de Brito Antonelli, Isabelle; Dammacco, Rosanna; Chimenti, Maria Sole; Arida, Katerina; Floris, Alberto; Gentile, Martina; Ruffilli, Francesca; Bellis, Elisa; Alunno, Alessia; Espinosa, Gerard; Gentileschi, Stefano; Gaggiano, Carla; Vitale, Antonio; Caggiano, Valeria; Lopez, Roberta; Tarsia, Maria; Monti, Sara; Hatemi, Gülen; Karakoç, Alican; Frassi, Micol; Giacomelli, Roberto; Tharwat, Samar; Thabet, Maissa; Ciccia, Francesco; Emmi, Giacomo; Viapiana, Ombretta; Şahin, Ali; Sebastiani, Gian Domenico; Batu, Ezgi Deniz; Ozen, Seza; Sener, Seher; Opris-Belinski, Daniela; Costi, Stefania; Conforti, Alessandro; Cattalini, Marco; Bartoloni, Elena; Akkoç, Nurullah; Gunduz, Ozgul Soysal; Conti, Giovanni; Maier, Armin; Giardina, Annarita; Li Gobbi, Francesca; Parronchi, Paola; Sarzi Puttini, Piercarlo; Breda, Luciana; De Paulis, Amato; Carreño, Ester; La Torre, Francesco; Więsik-Scewczyk, Ewa; de-la Torre, Alejandra; Mejía-Salgado, Germán; Shahram, Farhad; Guiducci, Serena; Maggio, Maria Cristina; Aragona, Emma; Rigante, Donato; Ciavarro, Alessandro; Önen, Fatos; Erten, Şükran; Insalaco, Antonella; Del Giudice, Emanuela; Barone, Patrizia; Gicchino, Francesca; Brucato, Antonio; Lo Gullo, Alberto; Mauro, Angela; Karamanakos, Anastasios; Balistreri, Alberto; Mazzei, Maria Antonietta; Frediani, Bruno; Fabiani, Claudia; Cantarini, Luca, Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry «JOINT BONE SPINE» , vol. 92 , n. 2 , 2025 , pp. 1-5

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