Publications

Authors:

Maiolini, Federica; Bassanello, Eleonora; Croce, Jacopo; Tinazzi, Elisa; Friso, Simonetta

Title:

Systemic autoinflammatory disease following COVID-19 mRNA vaccine: a severe and rare clinical presentation

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNAL AND EMERGENCY MEDICINE

ISSN of journal:

1828-0447

N° Volume:

20

Number or Folder:

4

Page numbers:

1-4

Keyword:

Autoinflammatory disease; Adult Onset Still Disease; Macrophage activation syndrome; SARS-CoV-2; hemophagocytosis; autoimmune disease; anakinra; massive cytokine “storm”

Short description of contents:

SARS-CoV-2 pandemic infection caused thousands of deaths and the vaccination was the life-saving tool but some adverse effects have been also described among patients such as redness at the injection site, fever, fatigue, headache, chills, vomiting, and urticaria. Although rare, some cases of systemic hyperinflammation after vaccination have been reported, highlighting the need for a precocious identification and treatment of severe clinical manifestation. We describe here Adult Onset Still Disease (AOSD) that developed after vaccination with mRNA COVID-19 vaccine and caused a macrophage activation syndrome. The pathogenetic mechanism underlying the occurrence of an autoimmune or autoinflammatory disease after a vaccination has not been yet clarified: a viral infection can trigger autoimmune or autoinflammatory diseases through the mechanisms of the molecular mimicry and the bystander activation.

Note:

Adult Onset of Still Disease (AOSD) that developed after vaccination with mRNA COVID-19 vaccine. The pathogenetic mechanism underlying the occurrence of an autoimmune or autoinflammatory disease after a vaccination has not been yet clarified: a viral infection can trigger autoimmune or autoinflammatory diseases through the mechanisms of the molecular mimicry and the bystander activation

Web page:

https://link.springer.com/article/10.1007/s11739-025-03965-9

Product ID:

145956

Handle IRIS:

11562/1162908

Last Modified:

May 24, 2025

Bibliographic citation:

Maiolini, Federica; Bassanello, Eleonora; Croce, Jacopo; Tinazzi, Elisa; Friso, Simonetta, Systemic autoinflammatory disease following COVID-19 mRNA vaccine: a severe and rare clinical presentation «INTERNAL AND EMERGENCY MEDICINE» , vol. 20 , n. 4 , 2025 , pp. 1-4

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