Publications

Authors:

Piraccini, B. M.; Pampaloni, F.; Cedirian, S.; Quadrelli, F.; Bruni, F.; Rapparini, L.; Caro, G.; Acri, M. C.; Ala, L.; Rossi, A.; Pellacani, G.; Lacarrubba, F.; Micali, G.; Dall'Oglio, F.; Vastarella, M.; Cantelli, M.; Nappa, P.; Diluvio, L.; Bianchi, L.; Gnesotto, L.; Sechi, A.; Naldi, L.; Tassone, F.; Peris, K.; Caldarola, G.; Pinto, L. M.; Girolomoni, G.; Marangoni, F.; Bellinato, F.; Gisondi, P.; Scandagli, I.; Prignano, F.; Pimpinelli, N.; Tomasini, C.; Barruscotti, S.; De Simoni, E.; Simonetti, O.; Ambrogio, F.; Foti, C.; Boccaletti, V.; Fraghì, A.; Marzano, A. V.; Mattioli, M. A.; Rocca, L.; Barbareschi, M.; Ferrucci, S. M.; Gallo, G.; Ribero, S.; Quaglino, P.; Balestri, R.; Ioris, T.; Caposiena Caro, R. D.; Zalaudek, I.; Vagnozzi, E.; Fargnol, M. C.; Caponio, C.; Rubegni, P.; Cinotti, E.; Trovato, E.; Romanelli, M.; Dini, V.; Manzo Margiotta, F.; Feliciani, C.; De Felici Del Giudice, M. B.; Atzori, L.; Sanna, S.; Lembo, S.; Raimondo, A.; Magnano, M.; Starace, M.

Title:

Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Journal of the European Academy of Dermatology and Venereology

ISSN of journal:

0926-9959

Page numbers:

1143-1151

Keyword:

Alopecia areata is an autoimmune Baricitinib, an oral inhibitor of Janus kinases 1 and 2, has been recently approved to treat alopecia areata

Short description of contents:

Background: Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows and eyelashes, for which treatments are limited. Baricitinib, an oral inhibitor of Janus kinases 1 and 2, has been recently approved to treat alopecia areata. Materials and Methods: We conducted a retrospective study involving 23 medical centres across Italy, enrolling patients affected by severe alopecia areata (SALT >50), for more than 6months. Clinical and trichoscopic assessment was performed at each visit and impact on quality of life, anxiety and depression were evaluated using the Skindex-16 and the Hospital Anxiety and Depression Scale (HADS), respectively. Results: A total of 118 patients were enrolled, with a mean age of 39 years and a mean SALT >95. The mean value of the SALT score decreased from an average of 96.6 (±8.23 sd) to 48 (±35.2 sd) after 24weeks of treatment and 42.3% of patients achieved a SALT 30, 31.3% a SALT 20 and 20.3% a SALT 10 by Week 24. Trichoscopic signs showed fewer yellow dots and black dots significantly earlier than hair regrowth. Adverse events during the treatment period (mild laboratory test abnormalities) were reported in 12.7% patients. No drop-out were registered. Conclusions: Data on the effectiveness and safety of baricitinib are promising and support the use of this drug in severe forms of AA, also in the early stages. We also suggest performing trichoscopy in order to reveal early response to therapy.

Product ID:

146294

Handle IRIS:

11562/1165007

Last Modified:

June 18, 2025

Bibliographic citation:

Piraccini, B. M.; Pampaloni, F.; Cedirian, S.; Quadrelli, F.; Bruni, F.; Rapparini, L.; Caro, G.; Acri, M. C.; Ala, L.; Rossi, A.; Pellacani, G.; Lacarrubba, F.; Micali, G.; Dall'Oglio, F.; Vastarella, M.; Cantelli, M.; Nappa, P.; Diluvio, L.; Bianchi, L.; Gnesotto, L.; Sechi, A.; Naldi, L.; Tassone, F.; Peris, K.; Caldarola, G.; Pinto, L. M.; Girolomoni, G.; Marangoni, F.; Bellinato, F.; Gisondi, P.; Scandagli, I.; Prignano, F.; Pimpinelli, N.; Tomasini, C.; Barruscotti, S.; De Simoni, E.; Simonetti, O.; Ambrogio, F.; Foti, C.; Boccaletti, V.; Fraghì, A.; Marzano, A. V.; Mattioli, M. A.; Rocca, L.; Barbareschi, M.; Ferrucci, S. M.; Gallo, G.; Ribero, S.; Quaglino, P.; Balestri, R.; Ioris, T.; Caposiena Caro, R. D.; Zalaudek, I.; Vagnozzi, E.; Fargnol, M. C.; Caponio, C.; Rubegni, P.; Cinotti, E.; Trovato, E.; Romanelli, M.; Dini, V.; Manzo Margiotta, F.; Feliciani, C.; De Felici Del Giudice, M. B.; Atzori, L.; Sanna, S.; Lembo, S.; Raimondo, A.; Magnano, M.; Starace, M., Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24-week Italian study «Journal of the European Academy of Dermatology and Venereology» , 2025 , pp. 1143-1151

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo