Pubblicazioni

Autori:

Cheema, Naila Arif; Castagna, Annalisa; Ambrosani, Francesca; Argentino, Giuseppe; Friso, Simonetta; Zurlo, Marco; Beri, Ruggero; Maule, Matteo; Vaia, Rachele; Senna, Gianenrico; Caminati, Marco

Titolo:

Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

CELLS

ISSN Rivista:

2073-4409

N° Volume:

14

Numero o Fascicolo:

7

Intervallo pagine:

1-25

Parole chiave:

T2 inflammation; Th2; asthma; epithelial cells; exosomes; extracellular vesicles; immune cells; intercellular crosstalk; personalized medicine

Breve descrizione dei contenuti:

Asthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on the underlying immunological mechanisms. Recently, extracellular vesicles (EVs), particularly exosomes, have gained increasing attention due to their pivotal role in intercellular communication and distal signaling modulation. In the context of asthma pathobiology, an increasing amount of experimental evidence suggests that EVs secreted by eosinophils, mast cells, dendritic cells, T cells, neutrophils, macrophages, and epithelial cells contribute to disease modulation. This review explores the role of EVs in profiling the molecular signatures of T2-high and T2-low asthma, offering novel perspectives on disease mechanisms and potential therapeutic targets.

Pagina Web:

https://www.mdpi.com/2073-4409/14/7/542

Id prodotto:

146525

Handle IRIS:

11562/1165775

ultima modifica:

28 giugno 2025

Citazione bibliografica:

Cheema, Naila Arif; Castagna, Annalisa; Ambrosani, Francesca; Argentino, Giuseppe; Friso, Simonetta; Zurlo, Marco; Beri, Ruggero; Maule, Matteo; Vaia, Rachele; Senna, Gianenrico; Caminati, Marco, Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation «CELLS» , vol. 14 , n. 7 , 2025 , pp. 1-25

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo