Publications

Authors:

Cheema, Naila Arif; Castagna, Annalisa; Ambrosani, Francesca; Argentino, Giuseppe; Friso, Simonetta; Zurlo, Marco; Beri, Ruggero; Maule, Matteo; Vaia, Rachele; Senna, Gianenrico; Caminati, Marco

Title:

Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

CELLS

ISSN of journal:

2073-4409

N° Volume:

14

Number or Folder:

7

Page numbers:

1-25

Keyword:

T2 inflammation; Th2; asthma; epithelial cells; exosomes; extracellular vesicles; immune cells; intercellular crosstalk; personalized medicine

Short description of contents:

Asthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on the underlying immunological mechanisms. Recently, extracellular vesicles (EVs), particularly exosomes, have gained increasing attention due to their pivotal role in intercellular communication and distal signaling modulation. In the context of asthma pathobiology, an increasing amount of experimental evidence suggests that EVs secreted by eosinophils, mast cells, dendritic cells, T cells, neutrophils, macrophages, and epithelial cells contribute to disease modulation. This review explores the role of EVs in profiling the molecular signatures of T2-high and T2-low asthma, offering novel perspectives on disease mechanisms and potential therapeutic targets.

Web page:

https://www.mdpi.com/2073-4409/14/7/542

Product ID:

146525

Handle IRIS:

11562/1165775

Last Modified:

June 28, 2025

Bibliographic citation:

Cheema, Naila Arif; Castagna, Annalisa; Ambrosani, Francesca; Argentino, Giuseppe; Friso, Simonetta; Zurlo, Marco; Beri, Ruggero; Maule, Matteo; Vaia, Rachele; Senna, Gianenrico; Caminati, Marco, Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation «CELLS» , vol. 14 , n. 7 , 2025 , pp. 1-25

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