Publications

Authors:

L. Benini; G. Cavallini; D. Zordan; P. Rizzotti; L. Rigo; G. Brocco; L. Perobelli; M. Zanchetta; P. Pederzoli; L. A. Scuro

Title:

A clinical evaluation of monoclonal (CA19-9, CA50, CA12-5) and polyclonal (CEA, TPA) antibody-defined antigens for the diagnosis of pancreatic cancer

Year:

1988

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nations of authors:

ITALIA

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Pancreas

ISSN of journal:

0885-3177

N° Volume:

3

Page numbers:

61-66

Keyword:

pancreatic cancer, diagnosis, Ca 19-9, pancreatic diseases

Short description of contents:

We measured in 193 patients, admitted to our wards for symptoms and signs suggestive of pancreatic or digestive malignancy, the serum levels of five tumor-associated antigens (CA 19-9, CA 50, CA 125, TPA, CEA) and we evaluated their diagnostic accuracy both when used alone and in combination. For CA 19-9 and CA 50 a sensitivity for pancreatic cancer as high as 92 and 88%, respectively, and specificity of 91.8% were found. A lower sensitivity vs. pancreatic cancer was found for the other tumor markers, and vs. the other digestive and nondigestive malignancies for all tumor markers (apart for CA 19-9 and CA 50 vs. biliary carcinomas). As for the combined assays, the best figures were found vs. pancreatic cancer for CA 19-9 plus CA 50, CA 50 plus CEA, CA 50 plus CA 125; a sensitivity by far worse vs. the other gastrointestinal cancers was found for all the possible combinations. We conclude that in selected symptomatic patients some tumor-marker determinations can be useful in identifying those with a high probability of harboring a pancreatic cancer, to be further studied or operated upon. The clinical relevance of this in patients already symptomatic is at present unclear.

Product ID:

1208

Handle IRIS:

11562/1208

Deposited On:

July 11, 2012

Last Modified:

November 2, 2016

Bibliographic citation:

L. Benini; G. Cavallini; D. Zordan; P. Rizzotti; L. Rigo; G. Brocco; L. Perobelli; M. Zanchetta; P. Pederzoli; L. A. Scuro, A clinical evaluation of monoclonal (CA19-9, CA50, CA12-5) and polyclonal (CEA, TPA) antibody-defined antigens for the diagnosis of pancreatic cancer «Pancreas» , vol. 3 , 1988 , pp. 61-66

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo