Publications

Authors:

Corrocher, Roberto; L. M., Bambara; Pacor, Maria Luisa; Stanzial, Annamaria; Biasi, Domenico

Title:

Different binding proteins for folic acid in serum of patients with acute hepatitis

Year:

1980

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Acta Haematologica

ISSN of journal:

0001-5792

N° Volume:

64

Page numbers:

281-4

Short description of contents:

Serum from 44 volunteers and 21 patients with acute hepatitis and 18 with cirrhosis were tested for the total and unsaturated folate binding capacity (TFBC-UFBC). A high level of TFBC was noted in acute hepatitis (p < 0.001) and in cirrhosis (p < 0.05), whereas only in the last case a reduced UFBC was present (p < 0.05). When serum from patients with acute hepatitis was eluted on Sephadex G-200 after incubation with radio-active folic acid (500 pg), two main peaks were observed, one in the exclusion peak of protein and the second in the position of the only binder found in normal serum (MW 43,000). A third small peak was also present in the position corresponding to a MW of 20,000. These findings documented the release of binders from hepatic cell when a massive necrosis of liver occurs.

Product ID:

1563

Handle IRIS:

11562/1563

Deposited On:

July 18, 2007

Last Modified:

April 17, 2025

Bibliographic citation:

Corrocher, Roberto; L. M., Bambara; Pacor, Maria Luisa; Stanzial, Annamaria; Biasi, Domenico, Different binding proteins for folic acid in serum of patients with acute hepatitis «Acta Haematologica» , vol. 64 , 1980 , pp. 281-4

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