Publications

Authors:

Capra, Franco; Casaril, M.; Stanzial, Annamaria; Gabrielli, G. B.; Marsilli, R.; Ferrari, S.; Corrocher, Roberto

Title:

[Plasma dehydroepiandrosterone sulfate and urine steroid excretion in hepatic cirrhosis]

Year:

1989

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Italiano

Format:

A Stampa

Referee:

Sì

Name of journal:

Recenti progressi in medicina

ISSN of journal:

0034-1193

N° Volume:

80

Page numbers:

4-8

Short description of contents:

In the present study we evaluated the alterations of plasma levels of dehydroepiandrosterone sulphate (DHEA-S) and of steroid-derivatives urinary excretion in cirrhotic patients compared with normal controls. 107 patients have been studied: 45 affected by liver cirrhosis (22 males and 23 females) both in compensated and in ascitic state, and 62 healthy controls (32 males and 30 females). In all patients we assayed plasma DHEA-S by RIA as well as common liver function tests; moreover gaschromatographic profile of adrenal steroid excretion was performed in daily urine. Our findings show a significantly lower DHEA-S in cirrhotic patients compared with healthy controls, both males (451.7 SD 440.3 ng/ml vs 1438.3 SD 604.8, p less than 0.001) and females (225.5 SD 152.6 ng/ml vs 974.0 SD 405.7, p less than 0.001). Variance analysis confirmed that the difference was significant both for compensated and uncompensated ones. We also found some interesting relationships between DHEA-S and liver function tests, cholesterol and age. Urinary steroids were markedly low in both sexes, particularly adrenal sexual fraction. Our data show clear disfunction in DHEA-S metabolism in liver cirrhosis, partially related with the severity of the disease.

Product ID:

1868

Handle IRIS:

11562/1868

Deposited On:

July 7, 2007

Last Modified:

October 19, 2022

Bibliographic citation:

Capra, Franco; Casaril, M.; Stanzial, Annamaria; Gabrielli, G. B.; Marsilli, R.; Ferrari, S.; Corrocher, Roberto, [Plasma dehydroepiandrosterone sulfate and urine steroid excretion in hepatic cirrhosis] «Recenti progressi in medicina» , vol. 80 , 1989 , pp. 4-8

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