Publications

Authors:

D. Schena; G. C. Chieregato; M. De Gironcoli; D. Girelli; O. Olivieri; A. M. Stanzial; R. Corrocher; A. Bassi; S. Ferrari; P. Perazzoli; P. Guarini; A. Barba

Title:

Increased erythrocyte membrane arachidonate and platelet malondialdehyde (MDA) production in psoriasis: normalization after fish-oil

Year:

1989

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nations of authors:

ITALIA

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Acta Dermato Venereologica. Supplementum

ISSN of journal:

0365-8341

N° Volume:

146

Page numbers:

42-44

Short description of contents:

Evidence exists of platelet activation and increased thromboxane B2 production in psoriasis. In 13 patients suffering from psoriasis, we determined the lipid composition of erythrocyte membrane, erythrocyte and platelet glutathione peroxidase activity (E-GSH-Px; Plt-GSH-Px), platelet MDA production and bleeding time. Compared with normal controls, psoriatics showed a significant increase in erythrocyte membrane arachidonic acid (AA) (p less than 0.001) and polyunsaturated fatty acids (PUFA) (p less than 0.001), platelet MDA production (p less than 0.01) and E- and Plt-GSH-Px activity (p less than 0.01; p less than 0.01). After 8 weeks of fish-oil supplementation (20 ml/day) we observed the following changes: a) marked amelioration of skin lesions; b) normalization of membrane lipid pattern and platelet MDA production; c) a further increase in E- and Plt-GSH-Px activity (p less than 0.01; p less than 0.01); d) significant prolongation of bleeding time (p less than 0.05). Our data demonstrate: 1) a generalized perturbation of membrane lipid pattern in psoriasis, characterized by an excess of AA; 2) an activation of AA metabolism in platelets suggested by increased MDA production and GSH-Px activity; 3) dietary fish-oil may normalize membrane lipid pattern and reduce platelet hyperactivity in psoriasis.

Product ID:

2090

Handle IRIS:

11562/2090

Deposited On:

July 20, 2007

Last Modified:

November 2, 2016

Bibliographic citation:

D. Schena; G. C. Chieregato; M. De Gironcoli; D. Girelli; O. Olivieri; A. M. Stanzial; R. Corrocher; A. Bassi; S. Ferrari; P. Perazzoli; P. Guarini; A. Barba, Increased erythrocyte membrane arachidonate and platelet malondialdehyde (MDA) production in psoriasis: normalization after fish-oil «Acta Dermato Venereologica. Supplementum» , vol. 146 , 1989 , pp. 42-44

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo