Publications

Authors:

Girelli, Domenico; Olivieri, Oliviero; Stanzial, Annamaria; M., Azzini; Lupo, Antonio; P., Bernich; C., Menini; L., Gammaro; Corrocher, Roberto

Title:

Low platelet glutathione peroxidase activity and serum selenium concentration in patients with chronic renal failure: relations to dialysis treatments, diet and cardiovascular complications

Year:

1993

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

CLIN SCI (LOND)

ISSN of journal:

0143-5221

N° Volume:

84

Page numbers:

611-7

Short description of contents:

1. Selenium status was investigated in patients with chronic renal failure, with special regard to its relations to the dialysis treatments, dietary habits and clinical signs of atherosclerosis. 2. Serum selenium concentration and platelet glutathione peroxidase activity were measured in 45 patients with chronic renal failure subdivided into three groups according to the type of treatment: 15 non-dialysed, 15 on haemodialysis, 15 on continuous ambulatory peritoneal dialysis. A 7-day diet history was carried out in all patients. Seventeen of the patients with chronic renal failure had clinically overt cardiovascular disease. Forty-five age-matched healthy subjects were considered as controls. 3. Both serum selenium concentration and platelet glutathione peroxidase were significantly reduced in all patients with chronic renal failure compared with control subjects; a direct and significant correlation was found between the two parameters. No differences in selenium status were observed among the non-dialysed, haemodialysis and continuous ambulatory peritoneal dialysis groups. No correlation between total calorie or protein intakes and selenium indices were observed. The chronic renal failure patients with cardiovascular complications showed a further significant reduction in both serum selenium concentration and platelet glutathione peroxidase activity as compared with the patients without cardiovascular complications; these two groups were similar with respect to the other well-known cardiovascular risk factors (age, smoking, plasma lipids, hypertension, body mass index). 4. It is concluded that a low selenium concentration is present in chronic renal failure, which is independent of dialysis and is accompanied by biological repercussion in terms of reduced platelet glutathione peroxidase activity.(ABSTRACT TRUNCATED AT 250 WORDS)

Product ID:

2377

Handle IRIS:

11562/2377

Deposited On:

August 8, 2007

Last Modified:

November 3, 2022

Bibliographic citation:

Girelli, Domenico; Olivieri, Oliviero; Stanzial, Annamaria; M., Azzini; Lupo, Antonio; P., Bernich; C., Menini; L., Gammaro; Corrocher, Roberto, Low platelet glutathione peroxidase activity and serum selenium concentration in patients with chronic renal failure: relations to dialysis treatments, diet and cardiovascular complications «CLIN SCI (LOND)» , vol. 84 , 1993 , pp. 611-7

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo