Publications

Authors:

A. M. Stanzial; L. Bonomi; C. Cobbe; O. Olivieri; D. Girelli; M. T. Trevisan; A. Bassi; S. Ferrari; R. Corrocher

Title:

Erythrocyte and platelet fatty acids in retinitis pigmentosa

Year:

1991

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nations of authors:

ITALIA

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Endocrinological Investigation

ISSN of journal:

0391-4097

N° Volume:

14

Page numbers:

295-302

Short description of contents:

The fatty acid composition and the glutathione-peroxidase activity (GSH-Px) of erythrocytes and platelets, the production of malondialdehyde (MDA) by platelets and the activity of the main systems of transmembrane cation transport in erythrocyte have been studied in 12 patients (5 males and 7 females) affected by retinitis pigmentosa (RP). A remarkable increase of saturated fatty acids (SFA), particularly of stearic acid (C18:0), has been noted in these patients. The reduced unsaturated/saturated fatty acids ratio (PUFA/SFA) observed in both erythrocytes and platelets and the decrease of arachidonic acid in platelets may depend by an active peroxidation process as documented by the increase of MDA. Platelet glutathione-peroxidase (PTL-GSH-PX) and plasma retinol were in the normal range, whereas erythrocyte glutathione-peroxidase (E-GSH-PX), MDA and plasma alfa-toco-pherol were increased in patients with RP. The activities of Na(+)-K+ pump, cotransport and Na(+)-Li+ countertransport were normal in RP erythrocytes.

Product ID:

2390

Handle IRIS:

11562/2390

Deposited On:

August 2, 2007

Last Modified:

November 2, 2016

Bibliographic citation:

A. M. Stanzial; L. Bonomi; C. Cobbe; O. Olivieri; D. Girelli; M. T. Trevisan; A. Bassi; S. Ferrari; R. Corrocher, Erythrocyte and platelet fatty acids in retinitis pigmentosa «Journal of Endocrinological Investigation» , vol. 14 , 1991 , pp. 295-302

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