Publications

Authors:

R. Corrocher; L. Guadagnin; M. De Gironcoli; D. Girelli; P. Guarini; O. Olivieri; S. Caffi; A. M. Stanzial; S. Ferrari; L. Grigolini

Title:

Membrane fatty acids, glutathione-peroxidase activity, and cation transport systems of erythrocytes and malondialdehyde production by platelets in Laurence Moon Barter Biedl syndrome

Year:

1989

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nations of authors:

ITALIA

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Endocrinological Investigation

ISSN of journal:

0391-4097

N° Volume:

12

Page numbers:

475-481

Short description of contents:

The fatty acid composition of erythrocyte membrane, the glutathione-peroxidase activity of erythrocytes and platelets, the production of malondialdehyde by platelets and the activity of the main systems of transmembrane cation transport have been studied in 5 members of a family, 2 of whom affected by Laurence-Moon-Barter-Biedl Syndrome. A remarkable increase of polyunsaturated fatty acids (particularly arachidonic acid) and of cholesterol/phospholipid molar ratio has been noted. This pattern of membrane lipids was associated to an increment of malondialdehyde production and an increase activity of glutathione-peroxidase. Serum retinol and a-tocopherol were in the normal range, whereas serum selenium was low in 3 out of 5 members. Moreover, the alteration of membrane lipids was associated to a decrease of the maximal velocity of Li-Na countertransport. We speculate that the enrichment of polyunsaturated fatty acids on the cell membranes may represent a condition favoring the lipoperoxidation and therefore the development of the retinitis pigmentosa characteristic feature of Laurence-Moon-Barter-Biedl Syndrome.

Product ID:

2395

Handle IRIS:

11562/2395

Deposited On:

July 7, 2007

Last Modified:

November 2, 2016

Bibliographic citation:

R. Corrocher; L. Guadagnin; M. De Gironcoli; D. Girelli; P. Guarini; O. Olivieri; S. Caffi; A. M. Stanzial; S. Ferrari; L. Grigolini, Membrane fatty acids, glutathione-peroxidase activity, and cation transport systems of erythrocytes and malondialdehyde production by platelets in Laurence Moon Barter Biedl syndrome «Journal of Endocrinological Investigation» , vol. 12 , 1989 , pp. 475-481

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