Publications

Authors:

Ambrosetti, Achille; G., Nadali; Vinante, Fabrizio; Ricetti, Maria Maddalena; Todeschini, Giuseppe; L., Morosato; D., De Sabata; Bergamo Andreis, I. a.; Chilosi, Marco; G., Semenzato; Pizzolo, Giovanni

Title:

Soluble interleukin-2 receptor in hairy cell leukemia: A reliable marker of disease

Year:

1993

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

International Journal of Clinical and Laboratory Research

ISSN of journal:

0940-5437

N° Volume:

23

Page numbers:

34-37

Keyword:

hairy cell leukemia; interleukin-2 receptor; interferon-alpha

Short description of contents:

The CD25 molecule, which corresponds to the p55 alpha chain of the interleukin-2 receptor, is strongly expressed by neoplastic cells in hairy-cell leukemia and is released in large amounts in the soluble form which is detectable in serum. In order to assess the reliability of the soluble interleukin-2 receptor as a disease marker in the management of patients with hairy-cell leukemia, we investigated serum levels in 35 untreated patients and in 2 patients with the hairy-cell leukemia variant. In 21 of 35 patients soluble receptor levels were also monitored during and after recombinant interferon-alpha therapy. Clinical and hematological parameters were also assessed. Soluble interleukin-2 receptor levels were extremely high at the time of diagnosis in patients with typical hairy-cell leukemia [32,722 +/- 27,001 vs. 331 +/- 145 units/ml in controls (mean +/- SD)], but not in patients with the leukemia variant. A progressive decrease in soluble interleukin-2 receptor levels paralleled the clinical response to treatment, although normal values were never detected, even in patients who achieved an apparent complete remission. After recombinant interferon-alpha discontinuation, disease recurrence was accompanied by a progressive increase to pre-treatment soluble receptor levels. Overall, a close correlation was found between soluble interleukin-2 receptor values and total tumor burden (r = 0.84, P < 0.001). On the basis of these data, soluble interleukin-2 receptor should be regarded as a key marker in the management of patients with hairy-cell leukemia.

Product ID:

7586

Handle IRIS:

11562/302164

Last Modified:

November 16, 2022

Bibliographic citation:

Ambrosetti, Achille; G., Nadali; Vinante, Fabrizio; Ricetti, Maria Maddalena; Todeschini, Giuseppe; L., Morosato; D., De Sabata; Bergamo Andreis, I. a.; Chilosi, Marco; G., Semenzato; Pizzolo, Giovanni, Soluble interleukin-2 receptor in hairy cell leukemia: A reliable marker of disease «International Journal of Clinical and Laboratory Research» , vol. 23 , 1993 , pp. 34-37

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