Publications

Authors:

G. Todeschini; S. Secchi; E. Morra; U. Vitolo; E. Orlandi; F. Pasini; E. Gallo; A. Ambrosetti; C. Tecchio; C. Tarella; A. Gabbas; A. Gallamini; L. Garzantini; M. Pizzuti; G. Fioritoni; L. Gottin; G. Rossi; M. Lazzarino; F. Menestrina; M. Paulli; M. Palestro; Mg. Cabras; F. Di Vito; G. Pizzolo

Title:

Primary mediastinal large B-cell lymphoma (PML-BCL):long term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B

Year:

2004

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

British Journal of Cancer

ISSN of journal:

0007-0920

N° Volume:

90

Page numbers:

372-376

Short description of contents:

The optimal treatment of primary mediastinal large B-cell lymphoma (PMLBCL) is still undefined. In the absence of randomised studies, we retrospectively analysed: (a) the effectiveness of two chemotherapy regimens (CHOP vs MACOP-B/VACOP-B) in complete remission (CR) achievement and event-free survival (EFS) and (b) the role of mediastinal involved-field radiotherapy (IF-RT) as consolidation. From 1982 to 1999, 138 consecutive patients affected by PMLBCL were treated in 13 Italian institutions with CHOP (43) or MACOP-B/VACOP-B (95). The two groups of patients were similar as regard to age, gender, presence of bulky mediastinal mass, pleural effusion, stage and international prognostic indexes category of risk. Overall, 75.5% of patients in CR received IF-RT as consolidation. Complete remission was 51.1% in the CHOP group and 80% in MACOP-B/VACOP-B (P<0.001). Relapse occurred in 22.7% of CHOP- and in 9.2% of MACOP-B/VACOP-B-treated patients (n.s.). Event-free patients were 39.5% in CHOP and 75.7% in the MACOP-B/VACOP-B group (P<0.001). The addition of IF-RT as consolidation improved the outcome, irrespectively of the type of chemotherapy (P=0.04). At a multivariate analysis, achievement of CR (P<0.0001) and type of CT (MACOP-B/VACOP-B) retained the significance for OS (P=0.008) and EFS (P=0.03). In our experience, MACOP-B/VACOP-B appears to positively influence OS and EFS in patients affected by PMLBCL, as compared to CHOP. Consolidation IF-RT on mediastinum further improves the outcome of CR patients.

Product ID:

23484

Handle IRIS:

11562/303421

Deposited On:

June 16, 2008

Last Modified:

May 22, 2017

Bibliographic citation:

G. Todeschini; S. Secchi; E. Morra; U. Vitolo; E. Orlandi; F. Pasini; E. Gallo; A. Ambrosetti; C. Tecchio; C. Tarella; A. Gabbas; A. Gallamini; L. Garzantini; M. Pizzuti; G. Fioritoni; L. Gottin; G. Rossi; M. Lazzarino; F. Menestrina; M. Paulli; M. Palestro; Mg. Cabras; F. Di Vito; G. Pizzolo, Primary mediastinal large B-cell lymphoma (PML-BCL):long term results from a retrospective multicentre Italian experience in 138 patients treated with CHOP or MACOP-B/VACOP-B «British Journal of Cancer» , vol. 90 , 2004 , pp. 372-376

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