Publications

Authors:

Cassatella, Marco Antonio; Pereira da Silva, G; Tinazzi, I; Facchetti, F; Scapini, Patrizia; Calzetti, Federica; Tamassia, Nicola; Wei, P; Nardelli, B; Roschke, V; Vecchi, A; Mantovani, A; Bambara, Lisa Maria; Edwards, Sw; Carletto, Antonio

Title:

Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.

Year:

2007

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Journal of Immunology

ISSN of journal:

0022-1767

N° Volume:

178

Page numbers:

7325-7333

Keyword:

Antigen-Antibody Complex; Arthritis; Rheumatoid; Cell Line; Tumor; Cells; Cultured; Cytokines; Humans; Immunoprecipitation; Monocytes; Polyethylene Glycols; Receptors; IgG; Solubility; Synovial Fluid; Synovial Membrane; Tumor Necrosis Factor Ligand Superfamily Member 15.

Short description of contents:

TNF-like cytokine (TL1A) is a newly identified member of the TNF superfamily of ligands that is important for T cell costimulation and Th1 polarization. However, despite increasing information about its functions, very little is known about expression of TL1A in normal or pathological states. In this study, we report that mononuclear phagocytes appear to be a major source of TL1A in rheumatoid arthritis (RA), as revealed by their strong TL1A expression in either synovial fluids or synovial tissue of rheumatoid factor (RF)-seropositive RA patients, but not RF-/RA patients. Accordingly, in vitro experiments revealed that human monocytes express and release significant amounts of soluble TL1A when stimulated with insoluble immune complexes (IC), polyethylene glycol precipitates from the serum of RF+/RA patients, or with insoluble ICs purified from RA synovial fluids. Monocyte-derived soluble TL1A was biologically active as determined by its capacity to induce apoptosis of the human erythroleukemic cell line TF-1, as well as to cooperate with IL-12 and IL-18 in inducing the production of IFN-gamma by CD4(+) T cells. Because RA is a chronic inflammatory disease with autoimmune etiology, in which ICs, autoantibodies (including RF), and various cytokines contribute to its pathology, our data suggest that TL1A could be involved in its pathogenesis and contribute to the severity of RA disease that is typical of RF+/RA patients.

Note:

Erratum in J Immunol. 2007 Jul 15;179(2):1390. da Silva, Gabriela Pereira [corrected to Pereira-da-Silva, Gabriela].

Product ID:

62826

Handle IRIS:

11562/308670

Deposited On:

March 28, 2012

Last Modified:

November 9, 2022

Bibliographic citation:

Cassatella, Marco Antonio; Pereira da Silva, G; Tinazzi, I; Facchetti, F; Scapini, Patrizia; Calzetti, Federica; Tamassia, Nicola; Wei, P; Nardelli, B; Roschke, V; Vecchi, A; Mantovani, A; Bambara, Lisa Maria; Edwards, Sw; Carletto, Antonio, Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. «Journal of Immunology» , vol. 178 , 2007 , pp. 7325-7333

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