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The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells.  (2008)

Authors:
Valenti MT; Dalle Carbonare L; Bertoldo F; Donatelli L; Lo Cascio V.
Title:
The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells.
Year:
2008
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
European Journal of Pharmacology
ISSN of journal:
0014-2999
N° Volume:
580
Number or Folder:
1-2
Page numbers:
36-42
Keyword:
hTERT expression; amino-bisphosphonate; Prostate Cancer
Short description of contents:
interference with themevalonate pathway. In addition, it is well known that gene expression of hTERT, the catalytic subunit of the telomerase, is elevated in prostatic cancer. In the prostate cancer cell lines we investigated the effects on hTERT gene expression of several bisphosphonates.We also evaluated whether the observed levels of expression were affected by the exposure to an analogue of the geranylgeranylpyrophosphate, the geranylgeraniol used to recover the mevalonate pathway. Our results showed that the amino-bisphosphonates down-regulate hTERT gene expression and that combined treatment with geranylgeraniol and zoledronate was able to revert only partially the effects on viability; on the contrary, hTERT gene down-regulation was not affected by the restoration of the mevalonate pathway. These results support the hypothesis that prostatic cancer cells are targeted by aminobisphosphonates also through a different mechanism from the mevalonate pathway.
Product ID:
40822
Handle IRIS:
11562/316931
Deposited On:
May 26, 2008
Last Modified:
August 16, 2021
Bibliographic citation:
Valenti MT; Dalle Carbonare L; Bertoldo F; Donatelli L; Lo Cascio V., The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells. «European Journal of Pharmacology» , vol. 580 , n. 1-22008pp. 36-42

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