Publications

Authors:

Olivieri, Oliviero; Pizzolo, Francesca; Ravagnani, Viviana; Moretti, Lorenzo; Carletto, A.; Faccini, Giovanni; Pasini, F.; Friso, Simonetta; Corrocher, Roberto

Title:

Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patients

Year:

2008

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Journal of Hypertension

ISSN of journal:

0263-6352

N° Volume:

26

Number or Folder:

3

Page numbers:

486-493

Note:

OBJECTIVE AND METHODS: Prednisone and its active metabolite prednisolone, both substrates for 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), may represent a pharmacological challenge for the enzyme. The aim of the present work was to define the possible role of abnormal cortisol/cortisone handling, as revealed by an urinary tetrahydrocortisol + allotetrahydrocortisol (THFs)/tetrahydrocortisone (THE) ratio between 1.5 and 3.0, by measuring urinary cortisol and cortisone metabolites in: normotensive individuals (n = 100) who received 7-8 mg/day of oral prednisone and were then followed for development of hypertension; essential hypertensive (EH) participants from primary care (n = 103); and EH hypertensive patients referred to the Hypertension Unit (n = 141). RESULTS: About one-third (14 out of 47, 30\%) of glucorticoid-treated patients who developed hypertension showed a THFs/THE ratio >1.5, which was seen in 3\% (n = 3) and 14\% (n = 19) of primary and tertiary care hypertensive patients, respectively. A THFs/THE ratio >1.5 was associated with a 3.8-fold incremental risk of hypertension after glucocorticoid therapy, regardless of duration and intensity of prednisone therapy. CONCLUSIONS: A number of EH patients and glucocorticoid-treated participants shared a similar phenotype, characterized by both arterial hypertension and elevated urinary THFs/THE ratio. Such a phenotype is more common in severely, rather than in mildly, hypertensive patients

Product ID:

45957

Handle IRIS:

11562/318059

Deposited On:

June 21, 2008

Last Modified:

November 8, 2022

Bibliographic citation:

Olivieri, Oliviero; Pizzolo, Francesca; Ravagnani, Viviana; Moretti, Lorenzo; Carletto, A.; Faccini, Giovanni; Pasini, F.; Friso, Simonetta; Corrocher, Roberto, Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patients «Journal of Hypertension» , vol. 26 , n. 3 , 2008 , pp. 486-493

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