Publications

11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension  (2009)

Authors:
Campino, C.; Carvajal, C. A.; Cornejo, J.; Martín, B. S.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Felice; Sateler, J.; Baudrand, R.; Mosso L., .; Owen, G. I.; Kalergis, A. M.; Padilla, O.; Fardella, C. E.
Title:
11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
ENDOCRINE
ISSN of journal:
1355-008X
N° Volume:
37
Number or Folder:
1
Page numbers:
106-114
Keyword:
hypertension; 11beta-hydroxysteroid; 5beta-reductase
Short description of contents:
Cortisol availability is modulated by several enzymes: 11beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5alpha- and 5beta-reductase) inactivate cortisol (together with 3alpha-HSD) to tetrahydrometabolites: 5alphaTHF, 5betaTHF, and THE. The aim was to assess 11beta-HSD2, 11beta-HSD1, and 5beta-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC-MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11beta-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11beta-HSD1 in compare to 11beta-HSD2 was inferred by the (5alphaTHF + 5betaTHF)/THE ratio and 5beta-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11beta-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5alphaTHF + 5betaTHF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11beta-HSD2 and 5beta-reductase decreased activity and imbalance of 11beta-HSDs should be considered in the future management of hypertensive patients.
Web page:
http://www.springerlink.com/content/l277761g2l45086k/
Product ID:
54243
Handle IRIS:
11562/340018
Last Modified:
November 9, 2022
Bibliographic citation:
Campino, C.; Carvajal, C. A.; Cornejo, J.; Martín, B. S.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Felice; Sateler, J.; Baudrand, R.; Mosso L., .; Owen, G. I.; Kalergis, A. M.; Padilla, O.; Fardella, C. E., 11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension «ENDOCRINE» , vol. 37 , n. 12009pp. 106-114

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