Publications

Authors:

Fattovich, Giovanna; Covolo, L; Pasino, Michela; Perini, E; Rossi, L; Brocco, Giorgio; Guido, M; Cristofori, C; Belotti, C; Puoti, M; Gaeta, Gb; Santantonio, T; Raimondo, G; Bruno, R; Minola, E; Negro, F; Donato, F; Italian Hepatitis C., Cohort Study Collaborative Group

Title:

The homestasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients.

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

LIVER INTERNATIONAL

ISSN of journal:

1478-3223

N° Volume:

31

Number or Folder:

1

Page numbers:

66-74

Keyword:

insulin resistance; hepatitis C; antiviral therapy

Short description of contents:

OBJECTIVES: To investigate the independent association between the homeostasis model assessment of the insulin resistance (HOMA-IR) score and rapid virological response (RVR) and sustained virological response (SVR) in chronic hepatitis C (CHC). METHODS: Observational prospective cohort study of 412 CHC patients [59% males; mean age 45 years; genotype 1 (44%), 2 (32%), 3 (19%) and 4 (5%)] treated with pegylated interferon α plus ribavirin. RESULTS: A HOMA-IR ≥2.0 was present in 49% and a metabolic syndrome in 4% of patients. By multivariate analysis, independent predictors of SVR were the lack of advanced fibrosis (≥F3) in genotype 1 and a lower body mass index in genotype 3 patients. In the subgroup of patients in whom HCV-RNA was evaluated at week 4 (n = 281), independent predictors of RVR were HCV-RNA <700,000 IU/ml, age <40 years and lower aspartate aminotransferase:alanine aminotransferase ratio in genotype 1 and baseline HOMA-IR ≤2 in genotype 3 patients. No predictive factor of RVR was identified among genotype 2 patients. RVR was the strongest predictor of SVR among genotype 1 or 3 patients. CONCLUSIONS: In this series of treatment-naïve, Caucasian CHC patients at a low risk for the metabolic syndrome, HOMA-IR is not a predictor of SVR, irrespective of the HCV genotype, although it may predict RVR in genotype 3 infection.

Note:

Comment in Insulin resistance and sustained virological response in hepatitis C: from bench to bedside. [Liver Int. 2011]

Product ID:

59048

Handle IRIS:

11562/346055

Deposited On:

February 10, 2011

Last Modified:

November 15, 2022

Bibliographic citation:

Fattovich, Giovanna; Covolo, L; Pasino, Michela; Perini, E; Rossi, L; Brocco, Giorgio; Guido, M; Cristofori, C; Belotti, C; Puoti, M; Gaeta, Gb; Santantonio, T; Raimondo, G; Bruno, R; Minola, E; Negro, F; Donato, F; Italian Hepatitis C., Cohort Study Collaborative Group, The homestasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients. «LIVER INTERNATIONAL» , vol. 31 , n. 1 , 2011 , pp. 66-74

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo