Publications

Authors:

Rossini, Maurizio; Adami, Silvano; Viapiana, Ombretta; Tripi, Gaia; Zanotti, Roberta; Ortolani, Riccardo; Vella, Antonio; Troplini, Sonila; Gatti, Davide

Title:

Acute Phase Response After Zoledronic Acid is Associated with Long-Term Effects on White Blood Cells.

Year:

2013

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Calcified Tissue International

ISSN of journal:

0171-967X

N° Volume:

93

Number or Folder:

3

Page numbers:

249-252

Keyword:

Acute phase response; zoledronic acid; white blood cells

Short description of contents:

We have recently reported a long-lasting decrease in circulating γδ T cells in osteoporotic patients on oral amino-bisphosphonates (N-BPs). Here we verify whether these changes are associated with the occurrence of acute phase response (APR) to intravenous (IV) zoledronic acid (ZOL) or changes of other circulating white blood cells (WBC). WBC count was obtained before and 1 year after a single IV administration of 5 mg ZOL in 36 osteoporotic patients (mean age 72 ± 9, range 45-86 years) without other relevant diseases; 12 of 36 patients developed the classical APR. After 1 year in the patients who experienced an APR, but not in the others, a significant decrease not only of γδ T cells (-30 %), but also of total lymphocytes (-11 %) and eosinophils (-27 %), was observed. The mechanism leading to the observed decrease of circulating lymphocytes and eosinophils remains unclear, but our observation opens a new frontier for the understanding of the immunoeffects of N-BPs.

Product ID:

78035

Handle IRIS:

11562/623956

Deposited On:

October 13, 2013

Last Modified:

November 15, 2022

Bibliographic citation:

Rossini, Maurizio; Adami, Silvano; Viapiana, Ombretta; Tripi, Gaia; Zanotti, Roberta; Ortolani, Riccardo; Vella, Antonio; Troplini, Sonila; Gatti, Davide, Acute Phase Response After Zoledronic Acid is Associated with Long-Term Effects on White Blood Cells. «Calcified Tissue International» , vol. 93 , n. 3 , 2013 , pp. 249-252

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